Document Detail

Effect of acute induced metabolic alkalosis on the acid/base responses to sprint exercise of six racing greyhounds.
MedLine Citation:
PMID:  8938856     Owner:  NLM     Status:  MEDLINE    
To investigate the effect of acute induced metabolic alkalosis on the haematological, biochemical and metabolic responses to sprint exercise, six greyhound dogs with previously placed carotid arterial catheters were raced four times over a distance of 400 metres. Each dog was raced twice after receiving oral sodium bicarbonate solution (NaHCO3) (400 mg kg-1) or lactated Ringer's solution (LRS). Before, and for intervals of up to one hour after, the exercise arterial blood samples were collected for the measurement of blood gases, packed cell volume, total protein, serum biochemistry and plasma lactate. The time to complete the 400 metre sprint ranged from 32.7 seconds to 36.9 seconds. There was no significant difference in racing times between the dogs treated with NaHCO3 and LRS, and there was no significant difference between the plasma lactate measurements after the treatments with NaHCO3 or LRS. Serum chloride concentrations were significantly lower after NaHCO3 than after LRS, and there was a trend towards a lower serum potassium concentration after NaHCO3 treatment. Plasma lactate concentrations showed a similar increase and time course of disappearance after both LRS and NaHCO3 treatments. There were significant changes in all the parameters measured after the exercise, but there were large variations between individual dogs and between races when the dogs were receiving the same treatment.
S A Holloway; D Sundstrom; D F Senior
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in veterinary science     Volume:  61     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-28     Completed Date:  1997-02-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville 32610, USA.
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MeSH Terms
Acid-Base Equilibrium* / drug effects
Administration, Oral
Blood Proteins / metabolism
Carbon Dioxide / blood
Electrolytes / blood
Hydrogen-Ion Concentration
Lactates / blood
Oxygen / blood
Partial Pressure
Physical Conditioning, Animal*
Physical Exertion*
Sodium Bicarbonate / administration & dosage,  pharmacology*
Time Factors
Reg. No./Substance:
0/Blood Proteins; 0/Electrolytes; 0/Lactates; 124-38-9/Carbon Dioxide; 144-55-8/Sodium Bicarbonate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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