Document Detail

Effect of acute hypoxia on lung fluid balance in the prerecruited dog lung.
MedLine Citation:
PMID:  3768567     Owner:  NLM     Status:  MEDLINE    
Lung lymph flow and protein transport were measured in eight anaesthetized dogs while acute hypoxic exposure (FIO2 = 0.10) was performed on prerecruited lung (achieved by an increased left atrial pressure). It was found that the lung lymph flow increase observed during hypoxia (from 71.8 +/- 47.5 to 100.8 +/- 78.4 microliters X min-1; p less than 0.05) was associated to an unchanged lymph/plasma protein concentration ratio (from 0.60 +/- 0.9 to 0.60 +/- 0.11). During recovery from hypoxia, lymph flow remained at a higher level than before hypoxia (respectively 87.8 +/- 49.5 and 71.8 +/- 47.5 microliters X min-1). These results suggest that the mild hypoxia-induced oedema is rather a high permeability oedema than an haemodynamic oedema. A graphic representation of protein clearance changes versus lymph flow changes was used in order to discriminate between high permeability and haemodynamic oedemas at their early stage.
D J Martin; P Baconnier; G Benchetrit; F Royer; F A Grimbert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin européen de physiopathologie respiratoire     Volume:  22     ISSN:  0395-3890     ISO Abbreviation:  Bull Eur Physiopathol Respir     Publication Date:    1986 Jul-Aug
Date Detail:
Created Date:  1986-12-02     Completed Date:  1986-12-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7605263     Medline TA:  Bull Eur Physiopathol Respir     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  335-40     Citation Subset:  IM    
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MeSH Terms
Anoxia / metabolism,  physiopathology*
Blood Proteins / metabolism*
Capillary Permeability
Lung / metabolism
Lymph / metabolism*
Myocardial Contraction
Pulmonary Edema / metabolism,  physiopathology*
Reg. No./Substance:
0/Blood Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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