Document Detail

Effect of acute hypoxia on cardiac function in alloxan-diabetic dogs.
MedLine Citation:
PMID:  3718428     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to examine the left ventricular and haemodynamic parameters during acute hypoxia induced by carbon monoxide intoxication and/or after norepinephrine administration in metabolically healthy and alloxan-diabetic dogs. In metabolically healthy animals after carbon monoxide intoxication followed by norepinephrine administration myocardial oedema occurred with a concomitant elevation of diastolic stiffness in the left ventricular wall, resulting in impaired cardiac performance. In the alloxan-diabetic animals no myocardial oedema developed and therefore no further increase of the originally elevated left ventricular diastolic stiffness could be observed. Close correlations were demonstrable between the enhanced water content and diastolic stiffness of the left ventricular wall in metabolically healthy animals as well as between the myocardial contractile force and cardiac output index in both control and diabetic dogs. In contrast to the controls, following norepinephrine administration per se decrease of cardiac performance could be observed in the alloxan-diabetic animals. Based on these results, it can be concluded that an increase of left ventricular diastolic stiffness impairs the cardiac performance in acute hypoxia following norepinephrine administration both in control and in diabetic animals, even if different reasons are responsible for it.
M Z Koltai; M Wagner; I Balogh; V Kiss; A Köszeghy; G Pogátsa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  81     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1986 Jan-Feb
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  92-100     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*
Carbon Monoxide Poisoning / physiopathology
Cardiac Output / drug effects
Diabetes Mellitus, Experimental / physiopathology*
Extracellular Space / metabolism
Heart Ventricles / physiopathology*
Hemodynamics* / drug effects
Myocardial Contraction / drug effects
Myocardial Infarction / physiopathology*
Myocardium / metabolism
Norepinephrine / pharmacology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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