Document Detail

Effect of acute high-intensity intermittent swimming on post-exercise insulin responsiveness in epitrochlearis muscle of fed rats.
MedLine Citation:
PMID:  19154959     Owner:  NLM     Status:  MEDLINE    
Maximally insulin-stimulated glucose uptake in skeletal muscle, ie, insulin responsiveness, is reduced in fed animals as compared with fasted animals; but acute prior endurance exercise improves insulin responsiveness in the muscles of fed rats. The effect of acute prior sprint interval exercise on insulin responsiveness in the muscles of fed animals has not been clarified, and we therefore compared the effect of short high-intensity swimming as a model of sprint interval exercise on insulin responsiveness in the muscles of fed rats with the effect of prolonged low-intensity swimming as a model of endurance exercise. The fed rats were subjected to an acute bout of high-intensity intermittent swimming (HIS) or low-intensity continuous swimming (LIS). The HIS rats swam for eight 20-second periods with a weight equal to 18% of their body weight. The LIS rats swam with no load for 3 hours. HIS increased (P < .05) the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) Thr(172) and that of its downstream target acetyl-CoA carboxylase (ACC) Ser(79) 12.6- and 3.1-fold, respectively, whereas LIS increased them 3.8- and 1.9-fold, respectively, immediately after exercise compared with rested muscle. HIS and LIS increased the insulin responsiveness of 2-deoxyglucose uptake measured 4 hours after exercise by 39% and 41%, respectively, compared with rested muscles. These results show that very short (160 seconds) HIS exercise with greater AMPK activation increases the responsiveness of glucose uptake to insulin in the muscles of fed rats to a similar level observed after prolonged (3 hours) LIS exercise with lower AMPK activation. Therefore, it is suggested that an acute bout of sprint interval exercise that activates AMPK to a sufficiently high level can increase post-exercise insulin responsiveness on muscle glucose uptake irrespective of very short exercise duration.
Keiichi Koshinaka; Emi Kawasaki; Fumi Hokari; Kentaro Kawanaka
Related Documents :
8587489 - Metabolite and hormonal response in smokers during rest and sustained exercise.
1930919 - Effect of exercise on pharmacokinetics.
6349619 - Sensitivity to insulin of glycolysis and glycogen synthesis of isolated soleus-muscle s...
7649909 - Effects of acute and chronic exercise on skeletal muscle glucose transport in aged rats.
10099719 - Lack of effects of an acute hepatic vagotomy on insulin and catecholamine responses in ...
3513629 - Regulation of hepatic glucose output during exercise by circulating glucose and insulin...
1687999 - Cardiac beta 2-adrenoceptors and the inotropic response to exercise in man.
7679869 - Reduction of exercise-induced ventricular arrhythmias in mild symptomatic heart failure...
12502159 - Using tactile features to help functionally blind individuals denominate banknotes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  58     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-02-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-53     Citation Subset:  IM    
Department of Health and Nutrition, Niigata University of Health and Welfare, Niigata City, Niigata 950-3198, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
AMP-Activated Protein Kinases / metabolism
Acetyl-CoA Carboxylase / metabolism
Blood Glucose / metabolism
Deoxyglucose / pharmacokinetics
Eating / physiology*
Glucose Transporter Type 4 / metabolism
Insulin / metabolism*
Insulin Resistance / physiology*
Muscle, Skeletal / physiology*
Phosphorylation / physiology
Physical Exertion / physiology*
Proto-Oncogene Proteins c-akt / metabolism
Rats, Wistar
Swimming / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Glucose Transporter Type 4; 0/Slc2a4 protein, rat; 11061-68-0/Insulin; 154-17-6/Deoxyglucose; EC Protein Kinases; EC Proteins c-akt; EC Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adiponectin isoform distribution in women--relationship to female sex steroids and insulin sensitivi...
Next Document:  Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and o...