Document Detail


Effect of acute high-intensity intermittent swimming on post-exercise insulin responsiveness in epitrochlearis muscle of fed rats.
MedLine Citation:
PMID:  19154959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maximally insulin-stimulated glucose uptake in skeletal muscle, ie, insulin responsiveness, is reduced in fed animals as compared with fasted animals; but acute prior endurance exercise improves insulin responsiveness in the muscles of fed rats. The effect of acute prior sprint interval exercise on insulin responsiveness in the muscles of fed animals has not been clarified, and we therefore compared the effect of short high-intensity swimming as a model of sprint interval exercise on insulin responsiveness in the muscles of fed rats with the effect of prolonged low-intensity swimming as a model of endurance exercise. The fed rats were subjected to an acute bout of high-intensity intermittent swimming (HIS) or low-intensity continuous swimming (LIS). The HIS rats swam for eight 20-second periods with a weight equal to 18% of their body weight. The LIS rats swam with no load for 3 hours. HIS increased (P < .05) the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) Thr(172) and that of its downstream target acetyl-CoA carboxylase (ACC) Ser(79) 12.6- and 3.1-fold, respectively, whereas LIS increased them 3.8- and 1.9-fold, respectively, immediately after exercise compared with rested muscle. HIS and LIS increased the insulin responsiveness of 2-deoxyglucose uptake measured 4 hours after exercise by 39% and 41%, respectively, compared with rested muscles. These results show that very short (160 seconds) HIS exercise with greater AMPK activation increases the responsiveness of glucose uptake to insulin in the muscles of fed rats to a similar level observed after prolonged (3 hours) LIS exercise with lower AMPK activation. Therefore, it is suggested that an acute bout of sprint interval exercise that activates AMPK to a sufficiently high level can increase post-exercise insulin responsiveness on muscle glucose uptake irrespective of very short exercise duration.
Authors:
Keiichi Koshinaka; Emi Kawasaki; Fumi Hokari; Kentaro Kawanaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  58     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-02-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-53     Citation Subset:  IM    
Affiliation:
Department of Health and Nutrition, Niigata University of Health and Welfare, Niigata City, Niigata 950-3198, Japan.
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MeSH Terms
Descriptor/Qualifier:
AMP-Activated Protein Kinases / metabolism
Acetyl-CoA Carboxylase / metabolism
Animals
Blood Glucose / metabolism
Deoxyglucose / pharmacokinetics
Eating / physiology*
Glucose Transporter Type 4 / metabolism
Insulin / metabolism*
Insulin Resistance / physiology*
Male
Muscle, Skeletal / physiology*
Phosphorylation / physiology
Physical Exertion / physiology*
Proto-Oncogene Proteins c-akt / metabolism
Rats
Rats, Wistar
Swimming / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Glucose Transporter Type 4; 0/Slc2a4 protein, rat; 11061-68-0/Insulin; 154-17-6/Deoxyglucose; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 6.4.1.2/Acetyl-CoA Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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