Document Detail

Effect of acute food deprivation on lactational infertility in rats is reduced by leptin administration.
MedLine Citation:
PMID:  9608020     Owner:  NLM     Status:  MEDLINE    
The goals of these experiments were to determine whether lactational anestrus would be prolonged by a 48-h fast at days 13 and 14 postpartum (pp) and, if so, to determine whether this effect could be reversed by treatment with the Ob protein leptin. We found that food deprivation on days 13 and 14 pp prolonged lactational infertility by 7 days and that the nutritional experience of both the dam and her litter contributed to this effect. Leptin administration (2.5 mg . kg-1 . day-1) during food deprivation was sufficient to reduce the length of lactational infertility compared with vehicle-treated food-deprived rats (P < 0.05). Similar leptin treatment in ad libitum-fed animals reduced food intake (P < 0.05) and litter growth (P < 0.05) but had no statistically significant effect on maternal weight gain or length of lactational infertility. Food-deprived lactating animals had lower circulating leptin levels than ad libitum-fed lactating animals on day 15 pp (P < 0.05), as determined by RIA. Levels in nonlactating rats were higher than in either lactating group (P < 0.05).
B Woodside; A Abizaid; S Jafferali
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-05     Completed Date:  1998-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1653-8     Citation Subset:  IM    
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada H4B 1R6.
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MeSH Terms
Anestrus / physiology
Animals, Newborn / growth & development
Diestrus / physiology
Food Deprivation / physiology*
Infertility, Female / etiology*
Lactation / physiology*
Proteins / analysis,  pharmacology*
Rats, Wistar
Time Factors
Weight Gain / drug effects
Reg. No./Substance:
0/Leptin; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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