| Effect of acute experimental pulmonary arterial occlusion on the deposition and clearance of technetium-99m-DTPA radioaerosols. | |
| | |
MedLine Citation:
|
PMID: 8046493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Canine models of autologous PE and balloon occlusion of the pulmonary vasculature were used to evaluate radioaerosol deposition and to quantify radioaerosol clearance in the immediate postembolic period. METHODS: A total of 28 animals were anesthetized, intubated and studied (central balloon occlusion = 4, peripheral balloon occlusion = 7, autologous PE = 5, various control groups = 12). A gamma camera computer system was used to monitor the distribution and clearance rate of inhaled DTPA radioaerosol. The perfusion defect distribution was determined after the radioaerosol study using 99mTc-MAA. RESULTS: A new radioaerosol deposition defect was seen in 3 of 16 animals in a zone of acute vascular occlusion by a balloon (n = 2) or PE (n = 1). In addition, radioaerosol clearance rates were altered substantially. Peripheral vascular occlusion and PE caused radioaerosol clearance rates to accelerate significantly (control clearance half-time = 33.6 +/- 4.6 min, post-balloon occlusion = 19.0 +/- 8.3 min, post-PE = 12.4 +/_ 3.7 min, both p < 0.05). In only one case did these clearance rate changes create a visible abnormality in the aerosol images. CONCLUSIONS: The pulmonary deposition patterns and clearance rates of 99mTc-DTPA radioaerosol can be altered by acute vascular occlusion or PE. These findings should be considered when interpreting radioaerosol images in patients with suspected PE. |
| | |
Authors:
|
Y Mori; P O Alderson; H L Berman |
Related Documents
:
|
8359303 - A prospective study of the natural history of femoropopliteal artery stenosis using dup... 1017183 - Sensitization to propantheline bromide, trichlorocarbanilide and propylene glycol in an... 1855243 - Increased arterial oxygen content--an important compensatory mechanism in chronic moder... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 35 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1994 Aug |
Date Detail:
|
Created Date: 1994-08-30 Completed Date: 1994-08-30 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1351-7 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Columbia-Presbyterian Medical Center, New York, NY 10032. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aerosols Animals Balloon Dilatation Dogs Lung / radionuclide imaging* Pulmonary Artery* Pulmonary Embolism / radionuclide imaging* Technetium Tc 99m Aggregated Albumin / diagnostic use Technetium Tc 99m Pentetate / diagnostic use* |
| Chemical | |
Reg. No./Substance:
|
0/Aerosols; 0/Technetium Tc 99m Aggregated Albumin; 65454-61-7/Technetium Tc 99m Pentetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multifocal osteonecrosis following chemotherapy and short-term corticosteroid therapy in a patient w...
Next Document: Immunotargeting of streptavidin to the pulmonary endothelium.