| Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia. | |
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MedLine Citation:
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PMID: 11876717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Altered visceral perception is common in functional dyspepsia (FD). Dopaminergic pathways control gastrointestinal motility, but whether they modulate visceral sensitivity is unknown. AIM: To investigate whether levosulpiride, a D2 antagonist, modulates gastric sensitivity and compliance in dyspeptic patients. METHODS: Eight healthy subjects and 16 dyspeptic patients underwent graded gastric distensions using a tensostat. In dyspeptic patients the same isotonic distensions were repeated during either levosulpiride or saline administration. Eight FD patients were evaluated after 4-week treatment with oral levosulpiride. Gastrointestinal symptoms were evaluated using a 100 mm visual analogue score. Perception was scored on a scale of 0 to 6. RESULTS: Although healthy subjects and FD patients had similar gastric compliance, FD patients tolerated lower tension levels. At the same distending tension levels, levosulpiride decreased gastric compliance and perception score (14 +/- 6% and 38 +/- 10% change, respectively; P < 0.05 vs. saline) only in FD patients. Isotonic distensions exhibited very reproducible perception. Chronic levosulpiride administration significantly reduced dyspeptic symptoms and increased discomfort threshold. CONCLUSIONS: Compared with healthy subjects, FD patients show marked gastric hypersensitivity. In FD patients levosulpiride decreased the perception of gastric distension with an action unrelated to change of gastric tone. Chronic levosulpiride administration significantly ameliorates gastrointestinal symptoms and increases the discomfort threshold. |
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Authors:
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E Distrutti; S Fiorucci; S K Hauer; M O Pensi; M Vanasia; A Morelli |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 16 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-05 Completed Date: 2002-06-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 613-22 Citation Subset: IM |
Affiliation:
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Gastroenterology Unit, University of Perugia, GiEnne Pharma, Milano, Italy. eleonoradistrutti@katamail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Double-Blind Method Drug Administration Schedule Dyspepsia / drug therapy, physiopathology* Female Gastric Emptying / drug effects*, physiology Gastrointestinal Agents / administration & dosage*, adverse effects, pharmacology*, therapeutic use Humans Middle Aged Muscle Tonus / drug effects Pressure Questionnaires Reproducibility of Results Stomach / drug effects*, physiopathology Sulpiride / administration & dosage*, adverse effects, analogs & derivatives*, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 15676-16-1/Sulpiride; 23672-07-3/levosulpiride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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