Document Detail

Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia.
MedLine Citation:
PMID:  11876717     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Altered visceral perception is common in functional dyspepsia (FD). Dopaminergic pathways control gastrointestinal motility, but whether they modulate visceral sensitivity is unknown. AIM: To investigate whether levosulpiride, a D2 antagonist, modulates gastric sensitivity and compliance in dyspeptic patients. METHODS: Eight healthy subjects and 16 dyspeptic patients underwent graded gastric distensions using a tensostat. In dyspeptic patients the same isotonic distensions were repeated during either levosulpiride or saline administration. Eight FD patients were evaluated after 4-week treatment with oral levosulpiride. Gastrointestinal symptoms were evaluated using a 100 mm visual analogue score. Perception was scored on a scale of 0 to 6. RESULTS: Although healthy subjects and FD patients had similar gastric compliance, FD patients tolerated lower tension levels. At the same distending tension levels, levosulpiride decreased gastric compliance and perception score (14 +/- 6% and 38 +/- 10% change, respectively; P < 0.05 vs. saline) only in FD patients. Isotonic distensions exhibited very reproducible perception. Chronic levosulpiride administration significantly reduced dyspeptic symptoms and increased discomfort threshold. CONCLUSIONS: Compared with healthy subjects, FD patients show marked gastric hypersensitivity. In FD patients levosulpiride decreased the perception of gastric distension with an action unrelated to change of gastric tone. Chronic levosulpiride administration significantly ameliorates gastrointestinal symptoms and increases the discomfort threshold.
E Distrutti; S Fiorucci; S K Hauer; M O Pensi; M Vanasia; A Morelli
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  16     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-05     Completed Date:  2002-06-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  613-22     Citation Subset:  IM    
Gastroenterology Unit, University of Perugia, GiEnne Pharma, Milano, Italy.
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MeSH Terms
Double-Blind Method
Drug Administration Schedule
Dyspepsia / drug therapy,  physiopathology*
Gastric Emptying / drug effects*,  physiology
Gastrointestinal Agents / administration & dosage*,  adverse effects,  pharmacology*,  therapeutic use
Middle Aged
Muscle Tonus / drug effects
Reproducibility of Results
Stomach / drug effects*,  physiopathology
Sulpiride / administration & dosage*,  adverse effects,  analogs & derivatives*,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Gastrointestinal Agents; 15676-16-1/Sulpiride; 23672-07-3/levosulpiride

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