Document Detail

Effect of activation of the serotoninergic system during prolonged starvation on subsequent caloric intake and macronutrient selection in the Zucker rat.
MedLine Citation:
PMID:  8507069     Owner:  NLM     Status:  MEDLINE    
Starvation or dietary restriction are known to modify post-fasting dietary self-selection. We have examined the effects of activation of the serotoninergic system and food deprivation on macronutrient self-selection following a period of starvation. Rats were starved for 4 days and either treated or not with dl-fenfluramine or fluoxetine. Starved untreated animals showed a post-fasting anorexia and an increased preference for carbohydrate intake, even though lipids remained the preferred source of calories. Treatment with fenfluramine or fluoxetine increased post-fasting anorexia, abolished the preference for carbohydrates and decreased lipid intake. Fluoxetine, but not fenfluramine, resulted in decreased protein intake as well. Following a 2-day refeeding period ad libitum, during which the animals were not treated with drugs, the anorectic effect of fenfluramine disappeared but that of fluoxetine remained unchanged. In addition, we noted that at an equimolar dose to dl-fenfluramine (100 mumol/kg/day) fluoxetine treatment resulted in the death of all the animals in the group by the second day of refeeding; no deaths were observed in any of the other groups. In conclusion, we confirm a post-starvation anorexia and increased carbohydrate intake following long-term fasting. In addition we show that activation of the serotoninergic system abolishes the increase in carbohydrate intake and potentiates post-starving anorexia.
J Duhault; F Lacour; J Espinal; Y Rolland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Appetite     Volume:  20     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-08     Completed Date:  1993-07-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  135-44     Citation Subset:  IM    
Institut de Recherches Servier, Suresnes, France.
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MeSH Terms
Dietary Carbohydrates / administration & dosage
Energy Intake*
Fenfluramine / pharmacology
Fluoxetine / pharmacology
Food Preferences*
Rats, Zucker
Serotonin / physiology*
Starvation / physiopathology*
Reg. No./Substance:
0/Dietary Carbohydrates; 458-24-2/Fenfluramine; 50-67-9/Serotonin; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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