Document Detail

Effect of acquired tolerance to ischemia on focal infarction in gerbils.
MedLine Citation:
PMID:  9095623     Owner:  NLM     Status:  MEDLINE    
The protective effect of prior ischemia on focal cerebral infarction produced by permanent middle cerebral artery (MCA) occlusion was studied in a gerbil model. Forebrain ischemia for 2 and 5 minutes at an interval of 48 hours was used as the prior ischemic insult. Forty-eight hours after the second forebrain ischemia, the MCA was occluded. Progression of ischemic change caused by the MCA occlusion was delayed in the early ischemic period in animals with prior ischemia, as compared to animals without prior ischemia. The mean infarct volume 24 hours after the MCA occlusion was the same in animals with and without prior ischemia. Ischemic tolerance was acquired in this model, but had no effect on the extent of infarction caused by permanent ischemia.
T Sorimachi; S Takeuchi; H Abe; R Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  37     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  236-42     Citation Subset:  IM    
Department of Neurosurgery, Brain Research Institute, Niigata University.
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MeSH Terms
Arterial Occlusive Diseases / metabolism*,  physiopathology
Cerebral Infarction / metabolism*,  physiopathology
Disease Models, Animal
HSP70 Heat-Shock Proteins / diagnostic use
Microtubule-Associated Proteins / diagnostic use
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; 0/Microtubule-Associated Proteins

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