Document Detail

Effect of acidosis on alpha 1- and alpha 2-adrenoceptor-mediated vasoconstrictor responses in isolated arteries.
MedLine Citation:
PMID:  3034639     Owner:  NLM     Status:  MEDLINE    
We have investigated the effect of reducing the pH (from 7.5 to 7.0 by addition of HCl) on vasoconstrictor responses to noradrenaline in cat middle cerebral artery (in which responses are mediated almost entirely by alpha 2-adrenoceptors) and in rabbit pulmonary artery (in which responses are mediated by alpha 1-adrenoceptors). In the cerebral artery, a reduction in pH caused a pronounced inhibition of the responses to noradrenaline, and the antagonistic effect of idazoxan (100 nM) was increased 10-fold. In contrast, in the pulmonary artery, a reduction in pH had no effect on the responses to noradrenaline and the antagonistic effect of prazosin (100 nM) was not altered. We conclude that acidosis selectively reduces the vasoconstriction mediated by alpha 2-adrenoceptors in vitro.
I C Medgett; P E Hicks; S Z Langer
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  135     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-07-17     Completed Date:  1987-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
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MeSH Terms
Acidosis / physiopathology*
Arteries / physiopathology
Hydrogen-Ion Concentration
Muscle, Smooth, Vascular / physiopathology*
Norepinephrine / physiology
Receptors, Adrenergic, alpha / physiology*
Species Specificity
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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