Document Detail

Effect of amoxycillin/clavulanic acid on the aerobic and anaerobic tonsillar microflora in the treatment of recurrent tonsillitis.
MedLine Citation:
PMID:  2284575     Owner:  NLM     Status:  MEDLINE    
30 patients with recurrent tonsillitis were treated with amoxycillin/clavulanic acid (500 mg/125 mg) t.i.d. for 10 days. The most often isolated potential aerobic pathogenic bacteria were Staphylococcus aureus, Streptococcus milleri and Haemophilus parainfluenzae. Group A streptococci were isolated from 7 patients. Anaerobic cocci and Bacteroides species were the dominating anaerobic bacteria isolated from the tonsils. Tonsillar cultures were taken before antibiotic treatment started, on days 11-12, day 30, and day 90. Beta-lactamase producing aerobic and anaerobic bacteria were present in 13 patients prior to treatment, on days 11-12 in 18 patients, on day 30 in 15 patients, and on day 90 in 13 patients. Group A streptococci were eradicated in 6/7 patients. In the aerobic tonsillar microflora, the numbers of viridans streptococci decreased during treatment but were normalized after 30 days. Only minor changes in the numbers of other aerobic microorganisms occurred during the investigation. The effect on the anaerobic microflora was minor and no new colonizing microorganisms were isolated during or after antibiotic treatment. All patients except one were cured on days 11-12. Five patients had another episode of tonsillitis during the observation period of 3 months. The antibiotic treatment was well tolerated in most patients and mild adverse events such as nausea, vomiting and diarrhoea were observed in 3 patients.
K Agren; C Lundberg; C E Nord
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  22     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM    
Department of Otorhinolaryngology, Karolinska Institute, Södersjukhuset, Sweden.
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MeSH Terms
Amoxicillin / therapeutic use*
Amoxicillin-Potassium Clavulanate Combination
Bacteria, Aerobic / drug effects
Bacteria, Anaerobic / drug effects
Bacterial Infections / drug therapy*,  microbiology
Clavulanic Acids / therapeutic use*
Drug Evaluation
Drug Therapy, Combination / therapeutic use
Tonsillitis / drug therapy*,  microbiology
Reg. No./Substance:
0/Clavulanic Acids; 26787-78-0/Amoxicillin; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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