Document Detail

Effect of acetazolamide on ventilatory response in subjects with chronic mountain sickness.
MedLine Citation:
PMID:  18603026     Owner:  NLM     Status:  MEDLINE    
Although the effects of acetazolamide (ACZ) on ventilation during acute mountain sickness are well known, there are no studies assessing its effect on ventilatory response in chronic hypoxia. We studied this effect in patients with chronic mountain sickness (CMS). Subjects with CMS, living permanently at 4300 m, were assigned in a randomized, double-blind study to 250 mg/day (n=9) or to 500 mg/day (n=9) of ACZ. Resting end-tidal PET(O2) and end-tidal PET(CO2) were measured before and after 3 weeks of acetazolamide. Ventilatory responses were evaluated by the determination of sensitivity to hypoxia and to CO2. After treatment ventilatory response to hypoxia increased, resting PET(CO2) decreased, and ACZ caused a leftward shift in the position, but not a change in the slope of the ventilation (VE) versus PET(CO2) relationship. There were no differences between the two doses used. ACZ administration provides a beneficial effect on respiratory function of high altitude natives with CMS and thus it can be an effective therapy for the disease.
Maria Rivera-Ch; Luis Huicho; Patrick Bouchet; Jean Paul Richalet; Fabiola León-Velarde
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-06-17
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  162     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  184-9     Citation Subset:  IM    
Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Instituto de Investigaciones de Altura, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, Lima 31, Peru.
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MeSH Terms
Acetazolamide / therapeutic use*
Altitude Sickness / drug therapy*,  physiopathology*
Analysis of Variance
Anoxia / physiopathology
Anticonvulsants / therapeutic use*
Carbon Dioxide / pharmacology
Chronic Disease
Dose-Response Relationship, Drug
Double-Blind Method
Middle Aged
Respiratory Mechanics / drug effects*,  physiology
Reg. No./Substance:
0/Anticonvulsants; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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