| Effect of acetazolamide on leg endurance exercise at sea level and simulated altitude. | |
| | |
MedLine Citation:
|
PMID: 16499476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acetazolamide can be taken at sea level to prevent acute mountain sickness during subsequent altitude exposure. Acetazolamide causes metabolic acidosis at sea level and altitude, and increases SaO2 (arterial oxygen saturation) at altitude. The aim of the present study was to determine whether acetazolamide impairs muscle endurance at sea level but not simulated altitude (4300 m for <3 h). Six subjects (20+/-1 years of age; mean+/-S.E.M.) performed exhaustive constant work rate one-leg knee-extension exercise (25+/-2 W) once a week for 4 weeks, twice at sea level and twice at altitude. Each week, subjects took either acetazolamide (250 mg) or placebo orally in a double-blind fashion (three times a day) for 2 days. On day 2, all exercise bouts began approx. 2.5 h after the last dose of acetazolamide or placebo. Acetazolamide caused similar acidosis (pH) in all subjects at sea level (7.43+/-0.01 with placebo compared with 7.34+/-0.01 with acetazolamide; P<0.05) and altitude (7.48+/-0.03 with placebo compared with 7.37+/-0.01 with acetazolamide; P<0.05). However, endurance performance was impaired with acetazolamide only at sea level (48+/-4 min with placebo compared with 36+/-5 min with acetazolamide; P<0.05), but not altitude (17+/-2 min with placebo compared with 20+/-3 min with acetazolamide; P = not significant). In conclusion, lack of impairment of endurance performance by acetazolamide compared with placebo at altitude was probably due to off-setting secondary effects resulting from acidosis, e.g. ventilatory induced increase in SaO2 for acetazolamide compared with placebo (89+/-1 compared with 86+/-1% respectively; P<0.05), which resulted in an increased oxygen pressure gradient from capillary to exercising muscle. |
| | |
Authors:
|
Charles S Fulco; Steven R Muza; Dan Ditzler; Eric Lammi; Steven F Lewis; Allen Cymerman |
Related Documents
:
|
10433186 - Exercise-induced cerebral deoxygenation among untrained trekkers at moderate altitudes. 3457176 - Errors incurred in programming a fully adjustable articulator with a pantograph. 20417346 - Is hypoxia training good for muscles and exercise performance? 11817616 - The effect of exercise and rest duration on the generation of venous gas bubbles at alt... 9223536 - The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during e... 10647526 - Shoulder impingement in front-crawl swimming: ii. analysis of stroking technique. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Clinical science (London, England : 1979) Volume: 110 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-12 Completed Date: 2006-08-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
|
Languages: eng Pagination: 683-92 Citation Subset: IM |
Affiliation:
|
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine (USARIEM), Kansas Street, Natick, MA 01760-5007, USA. Charles.fulco@us.army.mil |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetazolamide
/
administration & dosage* Adult Altitude* Analysis of Variance Carbonic Anhydrase Inhibitors / administration & dosage* Double-Blind Method Female Humans Leg Male Muscle, Skeletal / physiology* Oxygen / blood Physical Endurance* |
| Chemical | |
Reg. No./Substance:
|
0/Carbonic Anhydrase Inhibitors; 59-66-5/Acetazolamide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nitric oxide modulation of ophthalmic artery blood flow velocity waveform morphology in healthy volu...
Next Document: Ammonium ion transport by the AMT/Rh homologue LeAMT1;1.