Document Detail

Effect of acephate (orthene) on tissue levels of thiamine, pyruvic acid, lactic acid, glycogen and blood sugar.
MedLine Citation:
PMID:  7298151     Owner:  NLM     Status:  MEDLINE    
Effect of Acephate, an organophosphorus insecticide, on tissue levels of thiamine, pyruvic acid, lactic acid, glycogen and blood sugar, has been studied. The albino rats, injected subcutaneously with Acephate (25 mg/10 gm body wt./day) for 4 weeks and 8 weeks, showed appreciable depletion of thiamine in liver, heart, kidney, brain and blood. The depletion of thiamine was found to be more after 8 weeks of Acephate injection. There was concomitant increase in pyruvic acid and lactic acid in various tissues. There was enormous depletion of glycogen in liver and slight rise in blood sugar concentration. The animals injected thiamine (120 micrograms/100 gm body wt./day) along with Acephate, showed more or less normal levels of thiamine, pyruvic acid, lactic acid, liver glycogen and blood sugar. The increase in pyruvic acid and lactic acid in tissues has been attributed to depletion of thiamine which is required of pyruvic acid oxidation. The increase in blood sugar has been attributed to the excess breakdown of glycogen.
S T Deotare; C H Chakrabarti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  25     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    1981 Jul-Sep
Date Detail:
Created Date:  1982-01-28     Completed Date:  1982-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / metabolism
Glycogen / metabolism
Insecticides / pharmacology*
Lactates / metabolism
Lactic Acid
Liver Glycogen / metabolism
Organothiophosphorus Compounds / pharmacology*
Pyruvates / metabolism
Pyruvic Acid
Thiamine / metabolism
Tissue Distribution
Reg. No./Substance:
0/Blood Glucose; 0/Insecticides; 0/Lactates; 0/Liver Glycogen; 0/Organothiophosphorus Compounds; 0/Pyruvates; 127-17-3/Pyruvic Acid; 30560-19-1/acephate; 50-21-5/Lactic Acid; 59-43-8/Thiamine; 9005-79-2/Glycogen

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