| Effect of acarbose on the increased plasma concentration of uric acid induced by sucrose ingestion. | |
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MedLine Citation:
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PMID: 18600518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sucrose is converted fructose and glucose, which may increase plasma uric acid concentration (pUA) through increased purine degradation and/or decreased uric acid (UA) excretion. To investigate effects of acarbose, an inhibitor of alpha-glucosidase, on the increased pUA from sucrose administration, we measured pUA and urinary UA excretion in 6 healthy subjects before and after administering sucrose, with and without co-administration of acarbose. Sucrose raised pUA by 10% (p < 0.01). However, excretion and fractional clearance of UA were unchanged. Sucrose and acarbose coadministration also increased pUA, but less than did sucrose alone (sucrose: 4.9 to 5.4 mg/dl; sucrose + acarbose, 4.7 to 4.9 mg/dl, p < 0.05) without changes in urinary excretion and fractional clearance of UA. Acarbose appears to attenuate the rise in pUA by sucrose ingestion by inhibiting sucrose absorption. |
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Authors:
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Y Moriwaki; T Inokuchi; T Ka; A Yamamoto; Z Tsutsumi; S Takahashi; T Yamamoto |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 27 ISSN: 1532-2335 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 631-3 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. moriwaki@hyo-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acarbose
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pharmacology* Blood Glucose / metabolism Eating Enzyme Inhibitors / pharmacology* Humans Insulin / blood Lactic Acid / blood Male Purines / blood Sucrose / administration & dosage, pharmacology* Uric Acid / blood* alpha-Glucosidases / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Enzyme Inhibitors; 0/Purines; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 56180-94-0/Acarbose; 57-50-1/Sucrose; 69-93-2/Uric Acid; EC 3.2.1.20/alpha-Glucosidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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