Document Detail

Effect of acarbose on the increased plasma concentration of uric acid induced by sucrose ingestion.
MedLine Citation:
PMID:  18600518     Owner:  NLM     Status:  MEDLINE    
Sucrose is converted fructose and glucose, which may increase plasma uric acid concentration (pUA) through increased purine degradation and/or decreased uric acid (UA) excretion. To investigate effects of acarbose, an inhibitor of alpha-glucosidase, on the increased pUA from sucrose administration, we measured pUA and urinary UA excretion in 6 healthy subjects before and after administering sucrose, with and without co-administration of acarbose. Sucrose raised pUA by 10% (p < 0.01). However, excretion and fractional clearance of UA were unchanged. Sucrose and acarbose coadministration also increased pUA, but less than did sucrose alone (sucrose: 4.9 to 5.4 mg/dl; sucrose + acarbose, 4.7 to 4.9 mg/dl, p < 0.05) without changes in urinary excretion and fractional clearance of UA. Acarbose appears to attenuate the rise in pUA by sucrose ingestion by inhibiting sucrose absorption.
Y Moriwaki; T Inokuchi; T Ka; A Yamamoto; Z Tsutsumi; S Takahashi; T Yamamoto
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  27     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-07     Completed Date:  2008-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-3     Citation Subset:  IM    
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
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MeSH Terms
Acarbose / pharmacology*
Blood Glucose / metabolism
Enzyme Inhibitors / pharmacology*
Insulin / blood
Lactic Acid / blood
Purines / blood
Sucrose / administration & dosage,  pharmacology*
Uric Acid / blood*
alpha-Glucosidases / antagonists & inhibitors
Reg. No./Substance:
0/Blood Glucose; 0/Enzyme Inhibitors; 0/Purines; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 56180-94-0/Acarbose; 57-50-1/Sucrose; 69-93-2/Uric Acid; EC

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