Document Detail


Effect of an abnormal sperm chromatin structural assay (SCSA) on pregnancy outcome following (IVF) with ICSI in previous IVF failures.
MedLine Citation:
PMID:  15804866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A high DNA fragmentation index (DFI) when performing the sperm chromatin structural (SCSA) assay was claimed to be so specific for male subfertility that even IVF and ICSI did not result in live pregnancies. The present study was designed to corroborate or refute these findings. The SCSA test was performed on the male partner from couples failing to have a successful pregnancy despite at least 2 previous IVF attempts. In contrast to the aforementioned studies, ongoing pregnancies were found despite working with a group of recalcitrant patients. Nevertheless, a high DFI score was associated with a trend for lower ongoing pregnancy rates especially related to a high miscarriage rate. Other more recent studies seem to support our conclusions. A high DFI score should influence a patient to choose IVF as a therapeutic modality sooner, especially with ICSI.
Authors:
J H Check; V Graziano; R Cohen; J Krotec; M L Check
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of andrology     Volume:  51     ISSN:  0148-5016     ISO Abbreviation:  Arch. Androl.     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806755     Medline TA:  Arch Androl     Country:  England    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
Affiliation:
laurie@ccivf.com
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MeSH Terms
Descriptor/Qualifier:
Chromatin / chemistry*
Female
Fertilization in Vitro*
Humans
Male
Pregnancy
Pregnancy Outcome*
Protein Conformation
Sperm Injections, Intracytoplasmic*
Spermatozoa / chemistry*
Chemical
Reg. No./Substance:
0/Chromatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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