Document Detail


Effect of Yinian Jiangya Yin on primary hypertension in early stage--a clinical observation on 40 patients.
MedLine Citation:
PMID:  21053621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To observe the effect of Yinian Jiangya Yin (Decoction for lowering blood pressure to prolong life) on patients with early hypertension and its mechanism on the function of vascular endotheliocytes.
METHODS: The 79 patients with early primary hypertension belonging to the TCM syndrome of stagnation of phlegm and blood stasis in meridians and hyperactivity of the liver-yang were randomly divided into a treatment group of 40 patients treated with Yinian Jiangya Yin and a control group of 39 patients treated with Tianma Gouteng Yin (Decoction of Gastrodia and Uncaria). The changes in score of TCM syndrome and in blood pressure before and after treatment were observed in the two groups. The contents of nitrogen monoxide (NO) and endothelin (ET) in serum after treatment were determined.
RESULTS: There was a statistical difference (P < 0.05) in score of TCM syndrome, effect of lowering blood pressure, and the contents of ET and NO in serum after treatment between the two groups.
CONCLUSION: The effect of Yinian Jiangya Yin on improving TCM syndrome of patients with primary hypertension in early stage and on lowering blood pressure may be related to its regulating the imbalanced condition between ET and NO for restoring the function of endothelium-dependent vasodilation.
Authors:
Yong-Hua Zhao; Yu-De Liu; Ying Guan; Nai-Wei Liu
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine     Volume:  30     ISSN:  0255-2922     ISO Abbreviation:  J Tradit Chin Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211546     Medline TA:  J Tradit Chin Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Affiliation:
TCM College, Macao University of Science and Technology, Macao, China. yhzhao@must.edu.mo
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Drugs, Chinese Herbal / therapeutic use*
Endothelins / blood
Female
Humans
Hypertension / blood,  diagnosis,  drug therapy*,  physiopathology
Male
Middle Aged
Nitric Oxide / blood
Yin Deficiency / blood,  diagnosis,  drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Endothelins; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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