| Effect of Xuezhikang, an extract from red yeast Chinese rice, on coronary events in a Chinese population with previous myocardial infarction. | |
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MedLine Citation:
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PMID: 18549841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Results of well-controlled prospective clinical trials showed the efficacy of lipid-lowering therapies in the reduction of cardiovascular (CV) events in western populations, but they were not reported with a Chinese population. This multicenter study was conducted to determine the effects of Xuezhikang (XZK), a partially purified extract of red yeast rice, on lipoprotein and CV end points in Chinese patients who experienced a previous myocardial infarction. Nearly 5,000 of these patients with average low-density lipoprotein cholesterol levels at baseline were randomly assigned either to placebo or to XZK daily for an average of 4.5 years. The primary end point was a major coronary event that included nonfatal myocardial infarction and death from coronary heart disease. Frequencies of the primary end point were 10.4% in the placebo group and 5.7% in the XZK-treated group, with absolute and relative decreases of 4.7% and 45%, respectively. Treatment with XZK also significantly decreased CV and total mortality by 30% and 33%, the need for coronary revascularization by 1/3, and lowered total and low-density lipoprotein cholesterol and triglycerides, but raised high-density lipoprotein cholesterol levels. In conclusion, long-term therapy with XZK significantly decreased the recurrence of coronary events and the occurrence of new CV events and deaths, improved lipoprotein regulation, and was safe and well tolerated. |
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Authors:
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Zongliang Lu; Wenrong Kou; Baomin Du; Yangfeng Wu; Shuiping Zhao; Osvaldo A Brusco; John M Morgan; David M Capuzzi; ; S Li |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-04-11 |
Journal Detail:
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Title: The American journal of cardiology Volume: 101 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-13 Completed Date: 2008-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1689-93 Citation Subset: AIM; IM |
Affiliation:
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Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, Peoples Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biological Products / pharmacology* China / epidemiology Cholesterol, LDL / blood*, drug effects Dietary Supplements Double-Blind Method Drugs, Chinese Herbal / administration & dosage, pharmacology*, therapeutic use Female Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hyperlipoproteinemias / blood, drug therapy*, epidemiology Male Middle Aged Morbidity / trends Myocardial Infarction / epidemiology, prevention & control* Prospective Studies Survival Rate / trends Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Cholesterol, LDL; 0/Drugs, Chinese Herbal; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/red yeast rice; 0/xuezhikang |
| Investigator | |
Investigator/Affiliation:
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Y S Xu / ; D F Gu / ; X Jia / ; Z Chen / ; J L Sun / ; J Chen / ; X H Yu / ; J H Wang / ; N Wang / ; R P Zheng / ; S H Zhang / ; C X Liu / ; L H Sun / ; Y C Zhao / ; Y Lin / ; J B Huang / ; D Y Hu / ; X C Yang / ; Y Z Liu / ; M M Gao / ; P Zhang / ; C X Deng / ; Y Liu / ; Z Q Li / ; Y Q Shi / ; T S Hu / ; Y Z Chen / ; S Tan / ; W R Zhao / ; G L Deng / ; W J Huang / ; J C Zhang / ; H Yu / ; Q S Shi / ; X Z Wang / ; B Jiang / ; X R Pan / ; L Li / ; P L Pu / ; M Q Shu / ; Q L Xu / ; J H Zhang / ; W H Ding / ; L Li / ; J J Yang / ; J L Su / ; W D Zhao / ; X Liu / ; L J Li / ; J F Yang / ; Q S Wang / ; T G Huang / ; L F Li / ; L J Zhou / ; J X Guo / ; W H Li / ; Z P Li / ; X G Zhang / ; X M Peng / ; Y W An / ; J Shu / ; L T Ma / ; H Ge / ; M J Zhang / ; Z R Lv / ; J H Li / ; J W Yang / ; L Zhang / ; Y L Cheng / ; J G Chen / ; C W Zhou / ; H H Zhang / ; Y L Huang / ; X F Qu / ; J J Li / ; H Guo / ; G X Wang / ; S Z Hao / ; S J Li / ; H S Chang / ; S M Zhou / ; H Q Liang / ; S J Cao / ; J G Liu / ; J Yang / ; M Y Zhao / ; Y Lv / ; S L Xu / ; Z L Wang / ; S P Zhao / ; X P Li / ; X L Luo / ; Y P Li / ; Y Lei / ; S Q Fan / ; L H Wang / ; L J Zhao / ; Y C Zhao / ; S W Xue / ; J Li / ; S Y Xu / ; Y G Cao / ; B G Tong / ; W Wang / ; S K Xu / ; H Z Chen / ; W L Guo / ; L J Wang / ; X M Yan / ; X F Jing / ; C H Wang / ; B X Tang / ; H Bai / ; L Li / ; Y Liu / ; Y P Li / ; F Mei / ; K Z Yuan / ; Y Zhang / ; Y R Sun / ; L Chen / ; S R Xue / ; J P Wang / ; B Li / ; Z M Liu / ; L H Shen / ; J R Liang / ; Y Zhang / ; Y L Song / ; Y M Sun / ; Z Wang / ; Y H Xu / ; W J Zhang / ; R Q Mu / ; K Q Li / ; Y P Wei / ; S M Wang / ; Y J Fan / ; K Y An / ; J Guo / ; A P Li / ; D Y Zeng / ; H Y Huo / ; Y Chen / ; L X Song / ; B Q Jiang / ; D J Guo / ; H Chen / ; L Li / ; Y Q Yin / ; Y M Mao / ; L Miao / ; Y J Guo / ; S J Li / ; S S Cui / ; Q Diao / ; X M You / ; B Jiang / ; L T Zhu / ; J M Liu / ; L Fang / ; S G Lin / ; L Y Chen / ; W H Huang / ; Z G Zheng / ; Y N Ke / ; Y Wang / ; Q S Wang / ; H Liang / ; R Y Jia / ; T Wang / ; C X Liu / ; Q J Gen / ; B X Duan / ; C Q Fang / ; J Y Wang / ; Z W Chang / ; Y Qi / ; X Wang / ; W S He / ; P Ye / ; Y C Liu / ; C L Li / ; J J Ye / ; B X He / ; X Y Zhang / ; X F Hong / ; R G Shi / ; W L Wei / ; J J Sun / ; Z C Li / ; X J Zhang / ; P He / ; W Gao / ; Y J He / ; H B Zhang / ; N D Li / ; X N He / ; G L Chen / ; J L Wang / ; G F Liang / ; G Z Dai / ; Q Wang / ; H Y Jin / ; Y Li / ; L P Wei / ; L Qiao / ; S S Gao / ; S Wang / ; Q Fang / ; S Q Tao / ; Z J Chen / ; L S Gong / ; J Z Li / ; Y S Xu / ; B Q Jiang / ; L H Shen / ; S L Liang / ; Y L Huang / ; Y Z Chen / ; Z R Lu / ; W R Kou / ; Z L Wang / ; G Z Dai / ; J H Zhang / ; J X Guo / ; D Y Zeng / ; S G Lin / ; B X He / ; Y F Wu / ; X G Wu / ; J L Wang / ; Z L Lu / ; W R Kou / ; B M Du / ; Y F Wu / ; Y Li / ; X W Qin / ; B L Chen / |
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