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Effect of White Matter Lesions on Brain Perfusion in Alzheimer's Disease.
MedLine Citation:
PMID:  23183589     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: This study examined the effect of white matter lesions (WMLs) on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD). Methods: Ninety-eight patients with AD were included in the study (40 men and 58 women; mean age, 78.1 years). Cognitive function was assessed using the Mini-Mental State Examination. Brain magnetic resonance imaging (MRI) and (99m)Tc ethyl cysteinate dimer single photon emission computed tomography were performed in all subjects. AD patients were divided into two subgroups according to the presence of WMLs on MRI. A voxel-by-voxel group analysis using Statistical Parametric Mapping 8 was used to detect the differences in rCBF between the two groups. Results: Fifty-seven of 98 AD patients (58%) showed mild to moderate WMLs on MRI. The prevalence of hypertension was significantly higher in AD patients with WMLs than in those without WMLs. AD patients with WMLs exhibited a significantly decreased rCBF in the anterior cingulate gyrus and insula, compared to AD patients without WMLs. Conclusion: We suggest that WMLs might influence brain regions associated with the limbic system in patients with AD.
Authors:
Noriyuki Kimura; Hiroshi Nakama; Kenichirou Nakamura; Yasuhiro Aso; Toshihide Kumamoto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-23
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  34     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  256-261     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Neurology and Neuromuscular Disorders, Oita University, Faculty of Medicine, Yufu, Japan.
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