Document Detail

Effect of White Matter Lesions on Brain Perfusion in Alzheimer's Disease.
MedLine Citation:
PMID:  23183589     Owner:  NLM     Status:  Publisher    
Background: This study examined the effect of white matter lesions (WMLs) on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD). Methods: Ninety-eight patients with AD were included in the study (40 men and 58 women; mean age, 78.1 years). Cognitive function was assessed using the Mini-Mental State Examination. Brain magnetic resonance imaging (MRI) and (99m)Tc ethyl cysteinate dimer single photon emission computed tomography were performed in all subjects. AD patients were divided into two subgroups according to the presence of WMLs on MRI. A voxel-by-voxel group analysis using Statistical Parametric Mapping 8 was used to detect the differences in rCBF between the two groups. Results: Fifty-seven of 98 AD patients (58%) showed mild to moderate WMLs on MRI. The prevalence of hypertension was significantly higher in AD patients with WMLs than in those without WMLs. AD patients with WMLs exhibited a significantly decreased rCBF in the anterior cingulate gyrus and insula, compared to AD patients without WMLs. Conclusion: We suggest that WMLs might influence brain regions associated with the limbic system in patients with AD.
Noriyuki Kimura; Hiroshi Nakama; Kenichirou Nakamura; Yasuhiro Aso; Toshihide Kumamoto
Related Documents :
23982959 - Quality of life and health care use in patients with arthralgias without synovitis is s...
24252049 - Safety and effectiveness of adalimumab in japanese rheumatoid arthritis patients: postm...
23675269 - Salivary ceruloplasmin ferroxidase & oxidase activities in celiac patients.
23946889 - Severe hemorrhagic colitis in a patient with chronic myeloid leukemia in the blastic ph...
24132699 - Repetitive transcranial magnetic stimulation transiently reduces punding in parkinson's...
23043069 - Myeloproliferative neoplasms in budd-chiari syndrome and portal vein thrombosis: a meta...
15055819 - Sensitivity, specificity and predictive value of the echocardiography and troponin-t te...
8931519 - Structure of a combination of functional independence measure and instrumental activity...
16889279 - Hymenoptera venom immunotherapy and field stings.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-23
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  34     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  256-261     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Neurology and Neuromuscular Disorders, Oita University, Faculty of Medicine, Yufu, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Engineering adherent bacteria by creating a single synthetic curli operon.
Next Document:  Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC/MS/MS.