Document Detail


Effect of weight loss after bariatric surgery on left ventricular mass and ventricular repolarization in normotensive morbidly obese patients.
MedLine Citation:
PMID:  22537356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effect of weight loss on ventricular repolarization in morbidly obese patients, 39 normotensive subjects whose baseline body mass indexes were ≥40 kg/m(2) before weight loss from bariatric surgery were studied. All patients were free of underlying organic heart disease, heart failure, and conditions that might affect ventricular repolarization. Twelve-lead electrocardiography and transthoracic echocardiography were performed just before surgery and at the nadir of postoperative weight loss. The corrected QT interval (QTc) was derived using Bazett's formula. QTc dispersion was calculated by subtracting the minimum from the maximum QTc on the 12-lead electrocardiogram. Echocardiographic left ventricular (LV) mass was indexed to height(2.7). The mean body mass index decreased from 42.8 ± 2.1 to 31.9 ± 2.2 kg/m(2) (p <0.0005). For the entire group, weight loss was associated with significant reductions in mean QTc (from 428.7 ± 18.5 to 410.5 ± 11.9 ms, p <0.0001) and mean QTc dispersion (from 44.1 ± 11.2 to 33.2 ± 3.3 ms, p <0.0005). Mean QTc and QTc dispersion decreased significantly with weight loss in patients with LV hypertrophy but not in subjects without LV hypertrophy. Multivariate analysis identified pre-weight loss LV mass/height(2.7) as the most important predictor of pre-weight loss QTc and QTc dispersion and also identified weight loss-induced change in LV mass/height(2.7) as the most important predictor of weight loss-induced changes in QTc and QTc dispersion. In conclusion, LV hypertrophy is a key determinant of QTc and QTc dispersion in normotensive morbidly obese patients. Regression of LV hypertrophy associated with weight loss decreases QTc and QTc dispersion.
Authors:
Rita Mukerji; Marius Petruc; John L Fresen; Boyd E Terry; Gurushankar Govindarajan; Martin A Alpert
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Publication Detail:
Type:  Journal Article     Date:  2012-04-24
Journal Detail:
Title:  The American journal of cardiology     Volume:  110     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-09-26     Revised Date:  2012-12-20    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Division of Cardiovascular Medicine, University of Missouri-Columbia, Columbia, Missouri.
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MeSH Terms
Descriptor/Qualifier:
Bariatric Surgery*
Cohort Studies
Electrocardiography
Female
Heart Ventricles / physiopathology*
Humans
Hypertrophy, Left Ventricular / physiopathology*
Male
Middle Aged
Obesity, Morbid / physiopathology*,  surgery*
Prospective Studies
Ventricular Remodeling*
Weight Loss*
Comments/Corrections
Comment In:
Am J Cardiol. 2012 Nov 15;110(10):1551-2   [PMID:  23102231 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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