Document Detail


The effect of water disinfection by-products on pregnancy outcomes in two southeastern US communities.
MedLine Citation:
PMID:  21915074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if exposure to disinfection by-products (DBPs) during gestation increases the risk of adverse birth outcomes, specifically term small for gestational age (SGA) birth, preterm birth (PTB), and very PTB (<32 weeks' gestation).
METHODS: We used weekly measurements total trihalomethanes (TTHMs), five haloacetic acids (HAA5), and total organic halides (TOX) collected from two distribution systems to evaluate the associations between DBP concentrations and term SGA, PTB, and very PTB using logistic regression.
RESULTS: We found no associations between DBPs and term-SGA. In the site with higher concentrations of bromine-containing DBPs, we found an association between TOX and PTB; this association was larger, though less precise, for very PTB.
CONCLUSIONS: Our results do not support an association between TTHMs or HAA5 and the birth outcomes investigated, but an association was found between increased TOX and PTB.
Authors:
Bethany Jablonski Horton; Thomas J Luben; Amy H Herring; David A Savitz; Philip C Singer; Howard S Weinberg; Katherine E Hartmann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  53     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  2012-02-22     Revised Date:  2014-04-17    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1172-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight*
Female
Fetal Growth Retardation / epidemiology*
Gestational Age
Humans
Hydrocarbons, Brominated / adverse effects,  analysis*
Hydrocarbons, Chlorinated / adverse effects,  analysis*
Infant, Newborn
Logistic Models
Odds Ratio
Pregnancy
Pregnancy Outcome
Premature Birth / epidemiology*
Southeastern United States
Trihalomethanes / adverse effects,  analysis
Water Purification*
Water Supply / analysis
Young Adult
Grant Support
ID/Acronym/Agency:
P30 ES010126/ES/NIEHS NIH HHS; P30E510126//PHS HHS; R24 HD050924/HD/NICHD NIH HHS; T32 ES007018/ES/NIEHS NIH HHS; T32ES007018/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Hydrocarbons, Brominated; 0/Hydrocarbons, Chlorinated; 0/Trihalomethanes
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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