| Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery. | |
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MedLine Citation:
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PMID: 12430668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: WBC-replete blood transfusion has been suggested as an independent cause of increased postoperative infection. STUDY DESIGN AND METHODS: A total of 597 patients undergoing elective coronary artery or heart valve surgery were randomly assigned to receive plasma-reduced (PR), buffy coat-depleted (BCD), or WBC-filtered (WCF) RBCs in the event of requiring blood transfusion. Details of postoperative course were recorded. Further information was collected from the patient's general practitioner 3 months after discharge. RESULTS: No significant difference in inpatient infection rates was observed among patients randomly assigned to receive PR, BCD, or WCF RBCs. When only those receiving transfusion were analyzed (n = 509), use of PR RBCs was associated with more events coded as infections (p < or = 0.05) compared with BCD or WCF RBCs. However, when events coded as urinary tract infections were excluded, there was no significant difference among the three groups. Follow-up performed after discharge showed no difference in readmission rates, but a higher reported rate of infection in those randomly assigned to receive WCF RBCs (p < 0.02). CONCLUSION: No evidence has been found, analyzed by intention to treat, that use of WBC-reduced, BCD, or WCF RBCs reduces postoperative inpatient infection in patients undergoing cardiac bypass surgery. |
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Authors:
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J P Wallis; C E Chapman; K E Orr; S C Clark; J R Forty |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transfusion Volume: 42 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-11-14 Completed Date: 2002-12-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 1127-34 Citation Subset: IM |
Affiliation:
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Department of Haematology, Freeman Hospital, High Heaton, Newcastle upon Tyne, United Kingdom. jonathan.wallis@tfh.nuth.northy.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Group Incompatibility Cardiac Surgical Procedures* Chemical Precipitation Coronary Artery Bypass* Cross Infection / epidemiology*, etiology England / epidemiology Erythrocyte Transfusion / adverse effects, methods* Female Filtration Follow-Up Studies Humans Incidence Leukocytes* Male Medical Errors Middle Aged Plasma Postoperative Complications / epidemiology*, etiology Risk Factors Surgical Procedures, Elective Urinary Tract Infections / epidemiology, etiology |
| Comments/Corrections | |
Comment In:
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Transfusion. 2002 Sep;42(9):1106-10
[PMID:
12430664
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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