| Effect of vitamin A deficiency on iron bioavailability. | |
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MedLine Citation:
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PMID: 20668371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin A deficiency alters iron status leading to an iron overload in tissues; however, the mechanism of this interaction is poorly understood. The present study aimed to assess the effect of vitamin A deficiency on iron bioavailability and utilization in rats. METHODS: Animals were divided into three groups of six rats each that were fed AIN-93G diet (control group), a vitamin A deficient diet and an iron and vitamin A deficient diet, respectively, for 57 days. The concentrations of hepatic and splenic iron, haemoglobin, red and white cells as well as iron utilization and its bioavailability were evaluated in the three groups. RESULTS: Vitamin A deficiency increased the concentration of red blood cells, haemoglobin concentration (Hb), and splenic iron as well as iron utilization. However, the iron bioavailability observed in vitamin A deficient rats was not significantly different compared to the control group, while in the iron/vitamin A deficient rats, it was higher (p = 0.0056). With regard to iron absorption, no difference was observed among the three groups. CONCLUSION: Increase of haemoglobin, red blood cells and splenic iron concentration observed in vitamin A deficiency suggests that vitamin A may affect the iron mobilization from tissues rather than iron absorption. |
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Authors:
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A Mehdad; E M A Siqueira; S F Arruda |
Publication Detail:
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Type: Journal Article Date: 2010-07-29 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 57 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 35-9 Citation Subset: IM |
Copyright Information:
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2010 S. Karger AG, Basel. |
Affiliation:
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Nutrition Department, University of Brasilia, Brazil. azadehmehdad@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Availability Iron / metabolism* Liver / drug effects, metabolism Male Rats Rats, Wistar Spleen / metabolism* Tissue Distribution Vitamin A / pharmacokinetics* Vitamin A Deficiency / metabolism* |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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