Document Detail

Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial.
MedLine Citation:
PMID:  23032549     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Observational studies have reported an inverse association between serum 25-hydroxyvitamin D (25-OHD) levels and incidence of upper respiratory tract infections (URTIs). However, results of clinical trials of vitamin D supplementation have been inconclusive.
OBJECTIVE: To determine the effect of vitamin D supplementation on incidence and severity of URTIs in healthy adults.
DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-blind, placebo-controlled trial conducted among 322 healthy adults between February 2010 and November 2011 in Christchurch, New Zealand.
INTERVENTION: Participants were randomly assigned to receive an initial dose of 200,000 IU oral vitamin D3, then 200,000 IU 1 month later, then 100,000 IU monthly (n = 161), or placebo administered in an identical dosing regimen (n = 161), for a total of 18 months.
MAIN OUTCOME MEASURES: The primary end point was number of URTI episodes. Secondary end points were duration of URTI episodes, severity of URTI episodes, and number of days of missed work due to URTI episodes.
RESULTS: The mean baseline 25-OHD level of participants was 29 (SD, 9) ng/mL. Vitamin D supplementation resulted in an increase in serum 25-OHD levels that was maintained at greater than 48 ng/mL throughout the study. There were 593 URTI episodes in the vitamin D group and 611 in the placebo group, with no statistically significant differences in the number of URTIs per participant (mean, 3.7 per person in the vitamin D group and 3.8 per person in the placebo group; risk ratio, 0.97; 95% CI, 0.85-1.11), number of days of missed work as a result of URTIs (mean, 0.76 days in each group; risk ratio, 1.03; 95% CI, 0.81-1.30), duration of symptoms per episode (mean, 12 days in each group; risk ratio, 0.96; 95% CI, 0.73-1.25), or severity of URTI episodes. These findings remained unchanged when the analysis was repeated by season and by baseline 25-OHD levels.
CONCLUSION: In this trial, monthly administration of 100,000 IU of vitamin D did not reduce the incidence or severity of URTIs in healthy adults.
TRIAL REGISTRATION: Identifier: ACTRN12609000486224.
David R Murdoch; Sandy Slow; Stephen T Chambers; Lance C Jennings; Alistair W Stewart; Patricia C Priest; Christopher M Florkowski; John H Livesey; Carlos A Camargo; Robert Scragg
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA     Volume:  308     ISSN:  1538-3598     ISO Abbreviation:  JAMA     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  2012-10-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1333-9     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Cholecalciferol / therapeutic use*
Double-Blind Method
Middle Aged
Respiratory Tract Infections / epidemiology*,  prevention & control*
Severity of Illness Index
Vitamin D / analogs & derivatives,  blood
Vitamins / therapeutic use*
Reg. No./Substance:
0/Vitamins; 1406-16-2/Vitamin D; 1C6V77QF41/Cholecalciferol; 64719-49-9/25-hydroxyvitamin D
Comment In:
JAMA. 2012 Oct 3;308(13):1375-6   [PMID:  23032554 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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