Document Detail

Effect of Vitamin C on Hyperoxia Induced Vasoconstriction in Exercising Skeletal Muscle.
MedLine Citation:
PMID:  25237186     Owner:  NLM     Status:  Publisher    
Hyperoxia can cause substantial reductions in peripheral and coronary blood flow at rest and during exercise, which may be caused by reactive oxygen species (ROS) generated during hyperoxia. The aim of this study was to investigate the role of ROS in hyperoxia-induced reductions in skeletal muscle blood flow during forearm exercise. We hypothesized that infusion of Vitamin C would abolish the effects of hyperoxia on the forearm blood flow (FBF) responses to exercise. Twelve young healthy adults performed rhythmic forearm handgrip exercise (10% of MVC for 5 minutes) during normoxia and hyperoxia. For each condition, two trials were conducted with intra-arterial administration of saline or Vitamin C. FBF was measured using Doppler ultrasound. During hyperoxia with saline, FBF and forearm vascular conductance (FVC) were 86.3±5.1% and 86.8±5.2% of the normoxic values (100%) (P<0.05). During Vitamin C, hyperoxic FBF and FVC responses were 90.9±4.2% and 90.9±4.1%, of the normoxic values (P = 0.57 and 0.59). Subjects were then divided into 3 sub-groups based on their percent decrease in FBF (> 20%, 10-20%, and < 10%) during hyperoxia. In the sub-group that demonstrated the greatest hyperoxia-induced changes (> 20%), FBF and FVC during hyperoxia were 67.1±4.0% and 66.8±3.6% of the normoxic values. Vitamin C abolished these effects on FBF and FVC with values that were 102.0±5.2% and 100.8±6.1%. However, Vitamin C had no effect in the other two sub-groups. This analysis is consistent with the idea that ROS generation blunts the FBF responses to exercise in the subjects most affected by hyperoxia.
Sushant M Ranadive; Michael J Joyner; Branton G Walker; Jennifer L Taylor; Darren P Casey
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-18
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, Journal of Applied Physiology.
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