Document Detail


Effect of vertical sleeve gastrectomy on food selection and satiation in rats.
MedLine Citation:
PMID:  22932782     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vertical sleeve gastrectomy (VSG) is a restrictive procedure that reduces food intake to produce weight loss. Here we assess volume and nutrient effects on the ingestive behavior of VSG and sham surgery animals. Rats given access to Ensure or pelleted chow were used to determine if liquid foods would adversely affect weight loss after surgery. Volume effects were studied by altering the caloric density of Ensure, and dietary preferences for fat and carbohydrate (sucrose) were assessed using a two-bottle test. c-Fos was used to measure neuronal activation in the nucleus of the solitary tract and area postrema in response to intragastric infusions of water, sucrose, or Intralipid. The degree of colocalization with catecholaminergic neurons was also assessed. VSG rats did not show the expected preference for a liquid diet over chow and lacked dietary preferences for fat seen in shams. Preferences for carbohydrate/sucrose solutions were unaffected by surgery. Meal size was reduced by VSG; however, VSG rats were able to alter their volume of intake to compensate for changes in caloric density, and intragastric infusions of water produced similar levels of neuronal activation among VSG, sham, and pair-fed rats. In comparison, nutrient-induced c-Fos activation was substantially increased by VSG. Colocalization between c-Fos and catecholaminergic-expressing neurons was similar among rats treated with water, sucrose, or Intralipid. VSG alters nutrient sensing in a manner that lowers the threshold for satiety and reduces fat preference to induce and maintain weight loss.
Authors:
Adam P Chambers; Hilary E Wilson-Perez; Sean McGrath; Bernadette E Grayson; Karen K Ryan; David A D'Alessio; Stephen C Woods; Darleen A Sandoval; Randy J Seeley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-28
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  303     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  2012-12-26     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1076-84     Citation Subset:  IM    
Affiliation:
Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA. adam.chambers@uc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Composition / drug effects
Body Weight / drug effects
Dietary Carbohydrates / pharmacology
Dietary Fats / pharmacology
Dopamine beta-Hydroxylase / metabolism
Eating / drug effects
Emulsions / pharmacology
Food Preferences / physiology*
Food, Formulated
Gastrectomy / methods*
Immunohistochemistry
Intubation, Gastrointestinal
Male
Phospholipids / pharmacology
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Long-Evans
Satiety Response / physiology*
Solitary Nucleus / drug effects,  physiology
Soybean Oil / pharmacology
Stomach / cytology,  drug effects,  metabolism
Sucrose / pharmacology
Water / pharmacology
Grant Support
ID/Acronym/Agency:
R01 DK093848/DK/NIDDK NIH HHS; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Emulsions; 0/Phospholipids; 0/Proto-Oncogene Proteins c-fos; 0/soybean oil, phospholipid emulsion; 57-50-1/Sucrose; 7732-18-5/Water; 8001-22-7/Soybean Oil; EC 1.14.17.1/Dopamine beta-Hydroxylase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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