| Effect of uterine artery embolization on uterine and leiomyoma perfusion: evidence of transient myometrial ischemia on magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 20685136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To document immediate and short-term changes in uterine perfusion after uterine artery embolization (UAE). MATERIALS AND METHODS: Fifteen patients (median age, 42 years) underwent UAE with tris-acryl gelatin microspheres and a limited embolization protocol. Contrast-enhanced magnetic resonance imaging was performed before therapy and 1 hour (immediate), 48-72 hours (subacute), and a median of 5 months (short-term follow-up) after UAE to determine uterine and leiomyoma perfusion. Leiomyomas with a minimum diameter of 10 mm were included. Changes in regional (ie, fundus/body/cervix), zonal (ie, endometrium/inner/middle and outer myometrial layer), and leiomyoma perfusion were documented. RESULTS: UAE was technically successful in all patients. Immediate contrast-enhanced MR imaging revealed ischemia of the uterine body and fundus. The endometrium and inner myometrial layer was involved in all 15 patients; the middle layer was also involved in 13. Ischemic defects were seen in the outer layer in one patient but never in the cervix. Subacute follow-up showed reperfusion of the myometrium in 73% of patients. Ischemic defects occurred in the endometrial and junctional zone in four patients and in the middle zone in one. Five-month follow-up showed perfusion of all uterine layers in all patients. Ten patients had complete infarction of all leiomyomas; five presented with 11 partially perfused leiomyomas. CONCLUSIONS: Limited bilateral UAE leads to transient uterine ischemia, particularly involving the endometrium and inner and middle zone of the myometrium of the uterine body and fundus. The cervix and subserosal layer are spared. Complete reperfusion of myometrial tissue is observed within 48-72 hours in most cases, whereas ischemic leiomyomas undergo irreversible infarction. |
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Authors:
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Christian Scheurig-Muenkler; Moritz Wagner; Tobias Franiel; Bernd Hamm; Thomas J Kroencke |
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Publication Detail:
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Type: Journal Article Date: 2010-08-03 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 21 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1347-53 Citation Subset: IM |
Copyright Information:
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Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. christian.scheurig@charite.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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therapeutic use Adult Contrast Media / diagnostic use Female Gelatin / therapeutic use Germany Humans Ischemia / pathology, physiopathology* Leiomyoma / blood supply, pathology, therapy* Magnetic Resonance Imaging* Middle Aged Myometrium / blood supply* Perfusion Imaging / methods* Prospective Studies Regional Blood Flow Time Factors Treatment Outcome Uterine Artery Embolization* / adverse effects Uterine Neoplasms / blood supply, pathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Contrast Media; 0/trisacryl gelatin microspheres; 9000-70-8/Gelatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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