Document Detail


Effect of ultrasound radiation force on the choroid.
MedLine Citation:
PMID:  23211817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: While visualization of the retina and choroid has made great progress, functional imaging techniques have been lacking. Our aim was to utilize acoustic radiation force impulse (ARFI) response to probe functional properties of these tissues.
METHODS: A single element 18-MHz ultrasound transducer was focused upon the retina of the rabbit eye. The procedure was performed with the eye proptosed and with the eye seated normally in the orbit. The transducer was excited to emit ARFI over a 10-ms period with a 25% duty cycle. Phase resolved pulse/echo data were acquired before, during, and following ARFI.
RESULTS: In the proptosed eye, ARFI exposure produced tissue displacements ranging from 0 to 10 μm, and an immediate increase in choroidal echo amplitude to over 6 dB, decaying to baseline after about 1 second. In the normally seated eye, ultrasound phase shifts consistent with flow were observed in the choroid, but enhanced backscatter following ARFI rarely occurred. ARFI-induced displacements of about 10 μm were observed at the choroidal margins. Larger displacements occurred within the choroid and in orbital tissues.
CONCLUSIONS: We hypothesize that elevated intraocular pressure occurring during proptosis induced choroidal ischemia and that acoustic radiation force produced a transient local decompression and reperfusion. With the eye normally seated, choroidal flow was observed and little alteration in backscatter resulted from exposure. Clinical application of this technique may provide new insights into diseases characterized by altered choroidal hemodynamics, including maculopathies, diabetic retinopathy, and glaucoma.
Authors:
Ronald H Silverman; Raksha Urs; Harriet O Lloyd
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-10
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-11     Completed Date:  2013-02-21     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / physiology
Choroid / blood supply,  ultrasonography*
Elasticity / physiology
Elasticity Imaging Techniques*
Exophthalmos / physiopathology
Intraocular Pressure / physiology
Ischemia / physiopathology,  ultrasonography
Ophthalmic Artery / physiology
Pulsatile Flow
Rabbits
Tonometry, Ocular
Transducers
Grant Support
ID/Acronym/Agency:
EY021529/EY/NEI NIH HHS; P30 EY019007/EY/NEI NIH HHS; R01 EY019055/EY/NEI NIH HHS; R01 EY021529/EY/NEI NIH HHS
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