Document Detail

The Effect of Two Different Parenteral Nutrition Regimens on Parenteral Nutrition Associated Cholestasis.
MedLine Citation:
PMID:  23205873     Owner:  NLM     Status:  Publisher    
Exposure to parenteral nutrition (PN) is one major factor in the development of cholestasis. The aim of this retrospective study was to compare the effect of these two different PN regimens on PN associated cholestasis. The files of the patients who have received different PN regimens for > 14 days in 2005 and 2009 were retrospectively reviewed. 133 patients have received PN more than 14 days. 22 (16.5%) patients had parenteral nutrition associated cholestasis. 90 neonates were in Group LDpn and 43 neonates in Group HDpn. Mean gestational age and birth weight were statistically significantly lower in LDpn Group (p=0.016, p=0.434). Cholestasis rate was significantly higher in high dose group. (p=0.023). Although several risk factors for PNAC are unavoidable, research is still needed to define the optimal parenteral amino acid solution for neonatal patients. Individualized parenteral nutrition may be more affective in allowing growth and minimizing side effects.
Ferda Ozlü; Hacer Yapıcıoğlu; Kurthan Mert; Mehmet Satar; Nejat Narlı; Yaşar Sertdemir
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Çukurova University, 1Neonatology Department, 2Biostatistic Department, Adana, Turkey.
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