Document Detail


Effect of Treponema hyodysenteriae infection on mucosal mast cells and T cells in the murine cecum.
MedLine Citation:
PMID:  2294059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenic mechanisms responsible for the development of lesions in swine and mice after infection with Treponema hyodysenteriae have not been fully characterized. The release of inflammatory mediators from mast cells has been postulated to play a role in lesion development during swine dysentery. Therefore, C3H/HeN mice were infected with T. hyodysenteriae, and mucosal mast cell (MMC) numbers were examined in cecal sections. An initial increase in MMC numbers from 13 to 22 per 50 crypt villus units was observed, but at 20 days postinfection the numbers significantly decreased (P less than 0.05) to 5 MMC per 50 crypt villus units. Immunohistochemical analysis performed on cecal sections failed to show a significant change in lamina proprial T-lymphocyte subsets. Numbers of T. hyodysenteriae CFU recovered from the cecum were stable throughout the experimental time period. Mast cell-deficient W/Wv mice and their mast cell-sufficient littermates were also infected to determine whether MMCs were necessary for the occurrence of T. hyodysenteriae-induced lesions. W/Wv mice were as susceptible to infection as their normal littermates and developed similar macroscopic and microscopic lesions. These results indicate that changes in MMC numbers can be detected after an infection with T. hyodysenteriae; however, on the basis of observations of infected W/Wv mice, mast cells are not required for lesion development in the murine model.
Authors:
S K Nibbelink; M J Wannemuehler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  58     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-01     Completed Date:  1990-02-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-92     Citation Subset:  IM    
Affiliation:
Department of Veterinary Microbiology, Iowa State University, Ames 50011.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cecum / immunology*,  pathology
Intestinal Mucosa / immunology
Mast Cells / immunology*
Mice
Mice, Inbred Strains
T-Lymphocytes / immunology*
Treponemal Infections / immunology*,  pathology
Comments/Corrections

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