Document Detail

Effect of treadmill exercise on serotonin immunoreactivity in medullary raphe nuclei and spinal cord following sciatic nerve transection in rats.
MedLine Citation:
PMID:  19774460     Owner:  NLM     Status:  MEDLINE    
The serotoninergic system modulates nociceptive and locomotor spinal cord circuits. Exercise improves motor function and changes dopaminergic, noradrenergic, and serotonergic central systems. However, the direct relationship between serotonin, peripheral nerve lesion and aerobic treadmill exercise has not been studied. Using immunohistochemistry and optic densitometry, this study showed that the sciatic nerve transection increased the serotoninergic immunoreactivity in neuronal cytoplasm of the magnus raphe nuclei of trained and sedentary rats. In the dorsal raphe nucleus the increase only occurred in sedentary-sham-operated rats. In the spinal cord of trained, transected rats, the ventral horn showed significant changes, while the change in dorsal horn was insignificant. Von Frey's test indicated analgesia in all exercise-trained rats. The sciatic nerve functional index indicated recovery in the trained group. Thus, both the aerobic treadmill exercise training and the nervous lesion appear to contribute to changes in serotonin immunoreactivity.
Arthiese Korb; Leandro Vi?osa Bonetti; Sandro Antunes da Silva; Simone Marcuzzo; Jocemar Ilha; Mariane Bertagnolli; Wania Aparecida Partata; Maria Cristina Faccioni-Heuser
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-23
Journal Detail:
Title:  Neurochemical research     Volume:  35     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380-9     Citation Subset:  IM    
Programa de P?s-Gradua??o em Neuroci?ncias, Instituto de Ci?ncias B?sicas da Sa?de, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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MeSH Terms
Citrate (si)-Synthase / metabolism
Hindlimb / physiology
Muscle, Skeletal / metabolism
Pain Measurement
Physical Conditioning, Animal / physiology*
Physical Endurance
Physical Stimulation
Raphe Nuclei / metabolism*
Rats, Wistar
Sciatic Nerve / physiology*
Serotonin / metabolism*
Spinal Cord / metabolism*
Reg. No./Substance:
50-67-9/Serotonin; EC (si)-Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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