Document Detail


Effect of Transcutaneous Electrical Stimulation on Rabbit Corneal Epithelial Cell Migration.
MedLine Citation:
PMID:  22333665     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To evaluate the effect of transcutaneous application of electrical stimulation on the rate of corneal epithelial healing in corneal abrasion using an in vivo model of corneal wound healing in the rabbit. METHODS: This was an experimental study including 16 adult Dutch rabbits that were randomly allocated to 2 study groups (8 in each group) to receive transcutaneous electrostimulation or no treatment. The corneal epithelium was lifted from the round limbal border. The rabbits in the study group received transcutaneous electrostimulation for 30 minutes by placing the active electrode (-) on the upper right lid and the passive electrode (+) on the right foot. Photographs of corneal epithelial defects were taken each day until the sixth day by digital photographs and the images were analyzed using software. RESULTS: The healing percentage was significantly higher in those who received transcutaneous electrostimulation at days 2 (P < 0.001), 3 (P < 0.001), 4 (P = 0.001), and 6 (P = 0.014) after the procedure. The healing rate was also significantly higher in the transcutaneous electrostimulation group at days 2 (P < 0.001), 5 (P = 0.022), and 6 (P = 0.044) after the procedure. The healing rate did not differ significantly between the groups at days 3 (P = 0.169) and 4 (P = 0.426). The maximum healing rate was observed in the first 24 hours, and the minimum healing rate was observed during day 3 in the electrical stimulation group. CONCLUSIONS: The transcutaneous application of electrical stimulation can considerably increase the rate of corneal healing, especially in the first 24 hours of healing full surface corneal abrasion.
Authors:
Alireza Ghaffarieh; Fariborz Ghaffarpasand; Maryam Dehghankhalili; Nazafarin Honarpisheh; Samira Nirumandi; Nader Tanideh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-13
Journal Detail:
Title:  Cornea     Volume:  -     ISSN:  1536-4798     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Dr Khodadoust Eye Hospital, Shiraz, Fars, Iran †Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI ‡Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran §Shiraz University of Medical Sciences, Shiraz, Iran ‖Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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