Document Detail


The effect of training status on the metabolic response of bone to an acute bout of exhaustive treadmill running.
MedLine Citation:
PMID:  20519353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Strenuous exercise increases bone resorption but not formation. The effect of improved training status is unknown. OBJECTIVE: Our objective was to examine the metabolic response of bone to strenuous running in recreationally active (RA) and endurance-trained (ET) men. DESIGN: Eleven RA, 10 ET, and 10 control (CON) subjects completed one 8-d trial. On d 4, RA and ET completed an exhaustive treadmill run. Blood was obtained at baseline (BASE), during exercise, during 2 h of recovery, and on four follow-up (FU) days (FU1-FU4). CON rested throughout, providing blood samples at BASE and on FU1-FU4. Markers of bone resorption [C-terminal telopeptide region of collagen type 1 (beta-CTX)] and bone formation [N-terminal propeptides of procollagen type 1 (P1NP) and bone alkaline phosphatase (ALP)], osteoprotegerin (OPG), PTH, albumin-adjusted calcium (ACa), and phosphate (PO4) were measured. RESULTS: There were no significant differences between ET and RA and no changes in CON for any variable. Exercise increased beta-CTX at FU1-FU4 (P<0.001) but had no effect on P1NP or bone ALP. OPG was increased after 20 min of exercise (P<0.001) and remained elevated at FU1 (P<0.001). PTH, ACa, and PO4 were increased throughout exercise (P<0.01). ACa and PO4 remained elevated in the 2 h after exercise (P<0.001), whereas PTH was lower than BASE from 1-2 h after exercise (P<0.001). CONCLUSION: After acute, exhaustive running, bone resorption but not formation was increased for 4 d in RA and ET men. The increased bone resorption might be related to the increase in PTH, whereas increased OPG might be a compensatory response to increased bone resorption. Training status did not significantly affect the metabolic response of bone to exhaustive running.
Authors:
Jonathan P R Scott; Craig Sale; Julie P Greeves; Anna Casey; John Dutton; William D Fraser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-02
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3918-25     Citation Subset:  AIM; IM    
Affiliation:
Human Protection and Performance Enhancement, Room G077, Building A54, QinetiQ, Cody Technology Park, Ively Road, Farnborough, Hampshire GU14 0LX, United Kingdom. jscott1@qinetiq.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Area Under Curve
Biological Markers / blood
Bone Resorption / metabolism*
Bone and Bones / metabolism*
Diet
Exercise / physiology*
Humans
Male
Osteogenesis / physiology
Osteoprotegerin / blood
Parathyroid Hormone / blood
Physical Exertion / physiology*
Physical Fitness / physiology*
Running
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Osteoprotegerin; 0/Parathyroid Hormone

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