| The effect of training status on the metabolic response of bone to an acute bout of exhaustive treadmill running. | |
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MedLine Citation:
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PMID: 20519353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Strenuous exercise increases bone resorption but not formation. The effect of improved training status is unknown. OBJECTIVE: Our objective was to examine the metabolic response of bone to strenuous running in recreationally active (RA) and endurance-trained (ET) men. DESIGN: Eleven RA, 10 ET, and 10 control (CON) subjects completed one 8-d trial. On d 4, RA and ET completed an exhaustive treadmill run. Blood was obtained at baseline (BASE), during exercise, during 2 h of recovery, and on four follow-up (FU) days (FU1-FU4). CON rested throughout, providing blood samples at BASE and on FU1-FU4. Markers of bone resorption [C-terminal telopeptide region of collagen type 1 (beta-CTX)] and bone formation [N-terminal propeptides of procollagen type 1 (P1NP) and bone alkaline phosphatase (ALP)], osteoprotegerin (OPG), PTH, albumin-adjusted calcium (ACa), and phosphate (PO4) were measured. RESULTS: There were no significant differences between ET and RA and no changes in CON for any variable. Exercise increased beta-CTX at FU1-FU4 (P<0.001) but had no effect on P1NP or bone ALP. OPG was increased after 20 min of exercise (P<0.001) and remained elevated at FU1 (P<0.001). PTH, ACa, and PO4 were increased throughout exercise (P<0.01). ACa and PO4 remained elevated in the 2 h after exercise (P<0.001), whereas PTH was lower than BASE from 1-2 h after exercise (P<0.001). CONCLUSION: After acute, exhaustive running, bone resorption but not formation was increased for 4 d in RA and ET men. The increased bone resorption might be related to the increase in PTH, whereas increased OPG might be a compensatory response to increased bone resorption. Training status did not significantly affect the metabolic response of bone to exhaustive running. |
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Authors:
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Jonathan P R Scott; Craig Sale; Julie P Greeves; Anna Casey; John Dutton; William D Fraser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-02 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3918-25 Citation Subset: AIM; IM |
Affiliation:
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Human Protection and Performance Enhancement, Room G077, Building A54, QinetiQ, Cody Technology Park, Ively Road, Farnborough, Hampshire GU14 0LX, United Kingdom. jscott1@qinetiq.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Area Under Curve Biological Markers / blood Bone Resorption / metabolism* Bone and Bones / metabolism* Diet Exercise / physiology* Humans Male Osteogenesis / physiology Osteoprotegerin / blood Parathyroid Hormone / blood Physical Exertion / physiology* Physical Fitness / physiology* Running |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Osteoprotegerin; 0/Parathyroid Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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