Document Detail

Effect of Timolol vs. a postural orthotic on hand tremor during microsurgery.
MedLine Citation:
PMID:  12375295     Owner:  NLM     Status:  MEDLINE    
The efficacy of beta blockers to control hand tremor remains equivocal. This study evaluated the effectiveness of Timolol, as well as a postural orthotic, in reducing movement deviation during a laboratory exercise. Eleven volunteers completed three randomized trials involving administration of Timolol, a placebo, or a postural orthotic. Drug administration was blinded. Each trial consisted of a simulated 2-hr clinical procedure, punctuated by video recordings of the subject's hand motion during a standardized pattern of instrument movement. ECRL EMG activity and digital oxygen perfusion were also measured. Recordings were converted into estimates of linear variance at baseline and 1 and 2 hr. A repeated-measures ANOVA, or the Friedman test, were used to assess significant differences. Movement deviation, EMG activity, and oxygen perfusion were unaffected by the duration of exercise or treatment (P > or = 0.454). We conclude that none of the treatments accorded a significant benefit in allaying hand tremor.
John D Lubahn; Brian G Dickson; Timothy E Cooney
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Evaluation Studies; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microsurgery     Volume:  22     ISSN:  0738-1085     ISO Abbreviation:  Microsurgery     Publication Date:  2002  
Date Detail:
Created Date:  2002-10-10     Completed Date:  2003-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309230     Medline TA:  Microsurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-6     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Orthopaedics, Hamot Medical Center, 201 State Street, Erie, PA 16550, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Hand / physiology
Microsurgery / methods*
Middle Aged
Orthotic Devices*
Posture / physiology
Timolol / therapeutic use*
Tremor / prevention & control*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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