Document Detail


Effect of Tianhuang Granule on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage.
MedLine Citation:
PMID:  20697940     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the effect and mechanism of Tianhuang Granule (, THG) on: hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring, serum matrix metalloproteinase-9 (MMP-9) level observation, and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function de ficit).
METHODS: Sixty patients with ACH were equally randomized: into two groups by lottery, the control group and the THG group; all were treated with conventional therapy, but to the patients in the THG group, THG was given orally in addition for 28 days. Changes of ICP, MMP-9 expression, and NIHSS scores, as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients, were estimated and compared.
RESULTS: (1) ICP was lowered more significantly in the: THG group, showing a significant difference between groups on day 7 (P<0.05). (2) MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group. (3) The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3 (P<0.05), but in the control group, the day of significant reduction was delayed to day 14, and the degrees on day 7 and day 14 in the two groups were significantly different (P<0.05 and P<0.01). (4) NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28 (P<0.05 and P<0.01).
CONCLUSION: THG can effectively lower ICP, down-regulate MMP-9 expression, promote the absorption: of cerebral hematoma and hydrocephalus, and improve the nerve function, showing a clinical effectiveness than conventional therapy.
Authors:
Hui Liao; Jie Xu; Zhan-zeng Lin; Jia-yue Yang; Qiang Chen
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-08-10
Journal Detail:
Title:  Chinese journal of integrative medicine     Volume:  16     ISSN:  1672-0415     ISO Abbreviation:  Chin J Integr Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181180     Medline TA:  Chin J Integr Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  IM    
Affiliation:
Department of Integrative Chinese and Western Medicine, the Forth Central Hospital of Tianjin City, Tianjin 300140, China. liaohui_z@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Cerebral Hemorrhage / blood*,  complications,  drug therapy*,  physiopathology
Drugs, Chinese Herbal / pharmacology,  therapeutic use*
Female
Hematoma / complications,  physiopathology
Humans
Hydrocephalus / complications,  physiopathology
Intracranial Pressure / drug effects,  physiology*
Male
Matrix Metalloproteinase 9 / blood*
Middle Aged
Phytotherapy
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/tianhuang; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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