Document Detail


Effect of testosterone therapy for delayed growth and puberty in boys with inflammatory bowel disease.
MedLine Citation:
PMID:  20664179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: pubertal delay and growth retardation are common in children with inflammatory bowel disease (IBD).
AIMS: To assess pubertal status and growth in a group of boys with IBD undergoing testosterone therapy for pubertal induction.
METHODS: retrospective study of height, weight and pubertal status in 8 boys with IBD before and after testosterone therapy. Height velocity (HV) over the 6 months before each assessment was converted to standard deviation score. Markers of disease activity and concomitant medication were recorded. Response was based on an advance in pubertal status and a greater than 50% increase in HV.
RESULTS: eight boys with IBD, median age 14.8 years, had pubertal induction using either monthly injections of 50 mg Sustanon or daily 2.5/5 mg Andropatch. Seven boys showed an advance of pubertal status. Six boys had a greater than 50% increase in HV; median HV at T0 was 1.6 cm/year (0, 5) compared with 6.9 cm/year (1, 11.7) at T6 (p = 0.005). C-reactive protein during testosterone therapy had a significant association with HV at T6 (r = -0.786; p = 0.021).
CONCLUSION: in most cases, testosterone therapy in boys with IBD and delayed growth and puberty is associated with an advance in pubertal status and an improvement in growth.
Authors:
A Mason; S C Wong; P McGrogan; S F Ahmed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-22
Journal Detail:
Title:  Hormone research in pædiatrics     Volume:  75     ISSN:  1663-2826     ISO Abbreviation:  Horm Res Paediatr     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-21     Completed Date:  2011-05-09     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101525157     Medline TA:  Horm Res Paediatr     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Androgens / therapeutic use*
Body Height / drug effects
Body Weight / drug effects
C-Reactive Protein / analysis
Growth Disorders / drug therapy*,  etiology
Humans
Inflammatory Bowel Diseases / blood,  physiopathology*
Kinetics
Male
Puberty, Delayed / drug therapy*,  etiology
Retrospective Studies
Testosterone / therapeutic use*
Chemical
Reg. No./Substance:
0/Androgens; 3XMK78S47O/Testosterone; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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