| Effect of testosterone therapy for delayed growth and puberty in boys with inflammatory bowel disease. | |
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MedLine Citation:
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PMID: 20664179 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Pubertal delay and growth retardation are common in children with inflammatory bowel disease (IBD). Aims: To assess pubertal status and growth in a group of boys with IBD undergoing testosterone therapy for pubertal induction. Methods: Retrospective study of height, weight and pubertal status in 8 boys with IBD before and after testosterone therapy. Height velocity (HV) over the 6 months before each assessment was converted to standard deviation score. Markers of disease activity and concomitant medication were recorded. Response was based on an advance in pubertal status and a greater than 50% increase in HV. Results: Eight boys with IBD, median age 14.8 years, had pubertal induction using either monthly injections of 50 mg Sustanon or daily 2.5/5 mg Andropatch. Seven boys showed an advance of pubertal status. Six boys had a greater than 50% increase in HV; median HV at T0 was 1.6 cm/year (0, 5) compared with 6.9 cm/year (1, 11.7) at T6 (p = 0.005). C-reactive protein during testosterone therapy had a significant association with HV at T6 (r = -0.786; p = 0.021). Conclusion: In most cases, testosterone therapy in boys with IBD and delayed growth and puberty is associated with an advance in pubertal status and an improvement in growth. |
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Authors:
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A Mason; S C Wong; P McGrogan; S F Ahmed |
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Publication Detail:
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Type: Journal Article Date: 2010-07-22 |
Journal Detail:
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Title: Hormone research in pædiatrics Volume: 75 ISSN: 1663-2826 ISO Abbreviation: Horm Res Paediatr Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525157 Medline TA: Horm Res Paediatr Country: Switzerland |
Other Details:
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Languages: eng Pagination: 8-13 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Developmental Endocrinology Research Group, University of Glasgow, Royal Hospital for Sick Children, Glasgow, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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