Document Detail


Effect of terminated fetal circulation on maternal angiogenic factors in severe early preeclampsia.
MedLine Citation:
PMID:  22380545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: We examined the course of angiogenic factors soluble fms-like tyrosine kinase-1 receptors (sFlt-1) and placental growth factor (PlGF) in a case of severe early PE in week 22 + 1 of gestation, when fetal termination was required to stabilize maternal condition.
RESULTS: The cessation of the feto-placental perfusion via fetocide led to a reduction of the maternal sFlt-1 concentration of 8.3% which was associated with a decline of the sFlt-1/PlGF ratio from 405 to 334. Nevertheless, the highest change of the angiogenic factors was detected after ejection of the fetus and placenta.
CONCLUSIONS: Our observations implicate that neither a vital fetus nor an intact feto-placental component is an obligatory prerequisite for the angiogenic imbalance that is associated with the preeclamptic phenotype.
Authors:
Alexander Jank; Jürgen Kratzsch; Holger Stepan
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-03-01
Journal Detail:
Title:  Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy     Volume:  31     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-09-18     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, University Hospital of Leipzig, Leipzig, Germany. alexander.jank@medizin.uni-leipzig.de
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MeSH Terms
Descriptor/Qualifier:
Abortion, Therapeutic*
Adult
Female
Humans
Pre-Eclampsia / blood,  therapy*
Pregnancy
Pregnancy Proteins / blood*
Pregnancy Trimester, Second
Vascular Endothelial Growth Factor Receptor-1 / blood*
Chemical
Reg. No./Substance:
0/Pregnancy Proteins; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
Comments/Corrections
Comment In:
Hypertens Pregnancy. 2013;32(1):94-5   [PMID:  23273068 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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