Document Detail

Effect of terminated fetal circulation on maternal angiogenic factors in severe early preeclampsia.
MedLine Citation:
PMID:  22380545     Owner:  NLM     Status:  MEDLINE    
AIM: We examined the course of angiogenic factors soluble fms-like tyrosine kinase-1 receptors (sFlt-1) and placental growth factor (PlGF) in a case of severe early PE in week 22 + 1 of gestation, when fetal termination was required to stabilize maternal condition.
RESULTS: The cessation of the feto-placental perfusion via fetocide led to a reduction of the maternal sFlt-1 concentration of 8.3% which was associated with a decline of the sFlt-1/PlGF ratio from 405 to 334. Nevertheless, the highest change of the angiogenic factors was detected after ejection of the fetus and placenta.
CONCLUSIONS: Our observations implicate that neither a vital fetus nor an intact feto-placental component is an obligatory prerequisite for the angiogenic imbalance that is associated with the preeclamptic phenotype.
Alexander Jank; Jürgen Kratzsch; Holger Stepan
Related Documents :
15172855 - Sudden death: ectopic pregnancy mortality.
12965095 - Unexpected fetal death during pregnancy--a problem of unrecognized fetal disorders duri...
22380545 - Effect of terminated fetal circulation on maternal angiogenic factors in severe early p...
17486465 - Pregnancy-related deaths due to pulmonary embolism in sweden.
6867145 - Exposure to ethanol during pregnancy in mice: potential importance of dose for the deve...
21693145 - Parity decreases methamphetamine-induced striatal dopaminergic perturbation.
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-03-01
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  31     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-09-18     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abortion, Therapeutic*
Pre-Eclampsia / blood,  therapy*
Pregnancy Proteins / blood*
Pregnancy Trimester, Second
Vascular Endothelial Growth Factor Receptor-1 / blood*
Reg. No./Substance:
0/Pregnancy Proteins; 144589-93-5/placenta growth factor; EC protein, human; EC Endothelial Growth Factor Receptor-1
Comment In:
Hypertens Pregnancy. 2013;32(1):94-5   [PMID:  23273068 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Extending the income inequality hypothesis: Ecological results from the 2005 and 2009 Argentine Nati...
Next Document:  Influence of polymers/excipients on development of agglomerated crystals of secnidazole by crystallo...