| The effect of tenofovir on vitamin D metabolism in HIV-infected adults is dependent on sex and ethnicity. | |
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MedLine Citation:
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PMID: 22984574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Tenofovir has been associated with renal phosphate wasting, reduced bone mineral density, and higher parathyroid hormone levels. The aim of this study was to carry out a detailed comparison of the effects of tenofovir versus non-tenofovir use on calcium, phosphate and, vitamin D, parathyroid hormone (PTH), and bone mineral density. METHODS: A cohort study of 56 HIV-1 infected adults at a single centre in the UK on stable antiretroviral regimes comparing biochemical and bone mineral density parameters between patients receiving either tenofovir or another nucleoside reverse transcriptase inhibitor. PRINCIPAL FINDINGS: In the unadjusted analysis, there was no significant difference between the two groups in PTH levels (tenofovir mean 5.9 pmol/L, 95% confidence intervals 5.0 to 6.8, versus non-tenofovir; 5.9, 4.9 to 6.9; p = 0.98). Patients on tenofovir had significantly reduced urinary calcium excretion (median 3.01 mmol/24 hours) compared to non-tenofovir users (4.56; p<0.0001). Stratification of the analysis by age and ethnicity revealed that non-white men but not women, on tenofovir had higher PTH levels than non-white men not on tenofovir (mean difference 3.1 pmol/L, 95% CI 5.3 to 0.9; p = 0.007). Those patients with optimal 25-hydroxyvitamin D (>75 nmol/L) on tenofovir had higher 1,25-dihydroxyvitamin D [1,25(OH)(2)D] (median 48 pg/mL versus 31; p = 0.012), fractional excretion of phosphate (median 26.1%, versus 14.6; p = 0.025) and lower serum phosphate (median 0.79 mmol/L versus 1.02; p = 0.040) than those not taking tenofovir. CONCLUSIONS: The effects of tenofovir on PTH levels were modified by sex and ethnicity in this cohort. Vitamin D status also modified the effects of tenofovir on serum concentrations of 1,25(OH)(2)D and phosphate. |
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Authors:
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Karen Klassen; Adrian R Martineau; Robert J Wilkinson; Graham Cooke; Alan P Courtney; Mary Hickson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-09-12 |
Journal Detail:
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Title: PloS one Volume: 7 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-17 Completed Date: 2013-03-12 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States |
Other Details:
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Languages: eng Pagination: e44845 Citation Subset: IM |
Affiliation:
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Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. k.klassen@qut.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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analogs & derivatives*,
pharmacology Adult Anti-HIV Agents / pharmacology* Bone Density Calcium / metabolism Cohort Studies Ethnic Groups Female HIV Infections / drug therapy*, ethnology Humans Male Middle Aged Organophosphonates / pharmacology* Parathyroid Hormone / metabolism Phosphates / metabolism Prospective Studies Regression Analysis Sex Factors Vitamin D / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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088316//Wellcome Trust; U.1175.02.002.00014.01//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Organophosphonates; 0/Parathyroid Hormone; 0/Phosphates; 107021-12-5/tenofovir; 1406-16-2/Vitamin D; 73-24-5/Adenine; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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