Document Detail


Effect of Temperature, Co-Solvent and Added Drug on Pluronic-Flurbiprofen Micellization.
MedLine Citation:
PMID:  22928957     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Structural changes in the micellization of Pluronics P103 and P123, as a function of temperature, co-solvent (ethanol, 10 v/v %), and the addition of the hydrophobic drug flurbiprofen were investigated by SANS and tensiometry. Addition of ethanol increases the critical micellization concentration of the Pluronics (making the polymer more soluble), whilst increasing the repulsive interactions between the flurbiprofen-Pluronic spherical complexes. However, increasing temperature and addition of drug increases both the aggregation number and core radius and leads to a more dehydrated core. The addition of flurbiprofen to Plutonic P103 was also found to reduce the critical micellization temperature from between 15 and 20°C to below 10°C and at higher drug concentrations leads to an attractive interaction between micelles and eventually phase separation.
Authors:
Shirin Alexander; Terence Cosgrove; Thomas C Castle; Isabelle Grillo; Stuart W Prescott
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-28
Journal Detail:
Title:  The journal of physical chemistry. B     Volume:  -     ISSN:  1520-5207     ISO Abbreviation:  J Phys Chem B     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157530     Medline TA:  J Phys Chem B     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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