| Effect of TRH and dopamine on cyclic AMP levels in enriched mammotroph and thyrotroph cells. | |
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MedLine Citation:
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PMID: 83946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Populations of normal anterior pituitary cells enriched in thyrotrophs or mammotrophs prepared by velocity sedimentation were used to investigate the effect of modulators of TSH and prolactin secretion on cyclic AMP accumulation. In both thyrotroph-enriched and mammotroph-enriched fractions, IBMX increased cyclic AMP accumulation. In the presence of IBMX, TRH invoked an increase in cyclic AMP suggesting that TRH modulates cyclic AMP accumulation in both of these cell types from normal pituitary glands. In the mammotroph-rich fraction, dopamine inhibited the increase in cyclic AMP induced by TRH. In contrast however, in the thyrotroph-enriched fraction dopamine lowered neither cyclic AMP concentration nor TSH secretion. Thus the inhibiting effect of dopamine on cyclic AMP appears to be specific for prolactin-secreting cells. |
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Authors:
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G D Barnes; B L Brown; T G Gard; D Atkinson; R P Ekins |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 12 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-04-28 Completed Date: 1979-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 273-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-3-isobutylxanthine
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pharmacology Animals Cyclic AMP / metabolism* Dopamine / pharmacology* Male Pituitary Gland, Anterior / cytology, drug effects, metabolism* Prolactin / secretion Rats Thyrotropin / secretion Thyrotropin-Releasing Hormone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 28822-58-4/1-Methyl-3-isobutylxanthine; 60-92-4/Cyclic AMP; 9002-62-4/Prolactin; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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