| Effect of TNP on the microbiology of venous leg ulcers: a pilot study. | |
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MedLine Citation:
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PMID: 19349936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effect of topical negative pressure, delivered using Vacuum Assisted Closure (VAC, KCI), on the microbiology of chronic, non-infected venous leg ulcers (VLUs). METHOD: Patients receiving compression therapy for a chronic VLU were recruited into this prospective pilot study. The ulcer was swabbed and VAC was applied at 125mmHg continuous sub-atmospheric pressure on day 1 for six days. Standard methods for bacteriological sampling and measuring the wound surface area were applied at baseline and at the VAC dressing changes on days 3 and 6. Log median colony forming units (CFUs) per cm2 were used for statistical analyses. The bacterial species were identified. RESULTS: Seven patients were recruited into and completed the study. The median log10 CFU/cm2 on days 1, 3 and 6 were 3.5, 4.7 and 5.1 respectively. There was a significant increase in bacterial colonisation between days 1 and 6 (p<0.02). No change was observed in the identified microbiological species during therapy with VAC. CONCLUSION: This pilot study suggests that VAC therapy increases absolute numbers of bacteria colonising non-infected leg ulcers. Declaration of interest: KCI supplied the VAC equipment and ARANZ the SilhouetteMobile, but both had no other influence on the study. |
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Authors:
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M Khashram; P Huggan; R Ikram; S Chambers; J A Roake; D R Lewis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of wound care Volume: 18 ISSN: 0969-0700 ISO Abbreviation: J Wound Care Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-07 Completed Date: 2009-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9417080 Medline TA: J Wound Care Country: England |
Other Details:
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Languages: eng Pagination: 164-7 Citation Subset: N |
Affiliation:
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Christchurch School of Medicine, University of Otago, New Zealand. manar.khashram@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Bacterial Infections / diagnosis, etiology*, prevention & control Chronic Disease Colony Count, Microbial Cross Infection / diagnosis, etiology*, prevention & control Female Humans Infection Control Male Middle Aged Negative-Pressure Wound Therapy* / adverse effects, methods Pilot Projects Prospective Studies Risk Factors Statistics, Nonparametric Time Factors Treatment Outcome Varicose Ulcer* / complications, therapy Wound Healing Wound Infection / diagnosis, etiology*, prevention & control |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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