| The effect of systematic medication review in elderly patients admitted to an acute ward of internal medicine. | |
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MedLine Citation:
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PMID: 20059474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elderly patients are vulnerable to medication errors and adverse drug events due to increased morbidity, polypharmacy and inappropriate interactions. The objective of this study was to investigate whether systematic medication review and counselling performed by a clinical pharmacist and clinical pharmacologist would reduce length of in-hospital stay in elderly patients admitted to an acute ward of internal medicine. A randomized, controlled study of 100 patients aged 70 years or older was conducted in an acute ward of internal medicine in Denmark. Intervention arm: a clinical pharmacist conducted systematic medication reviews after an experienced medical physician had prescribed the patients' medication. Information was collected from medical charts, interview with the patients and database registrations of drug purchase. Subsequently, medication histories were conferred with a clinical pharmacologist and advisory notes recommending medication changes were completed. Physicians were not obliged to comply with the recommendations. Control arm: medication was reviewed by usual routine in the ward. Primary end-point was length of in-hospital stay. In addition, readmissions, mortality, contact to primary healthcare and quality of life were measured at 3-month follow-up. In the intervention arm, the mean length of in-hospital stay was 239.9 hr (95% CI: 190.2-289.6) and in the control arm: 238.6 hr (95% CI: 137.6-339.6), which was neither a statistical significant nor a clinically relevant difference. Moreover, no differences were observed for any of the secondary end-points. Systematic medication review and medication counselling did not show any effect on in-hospital length of stay in elderly patients when admitted to an acute ward of internal medicine. |
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Authors:
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Marianne Lisby; Anette Thomsen; Lars Peter Nielsen; Nina Munk Lyhne; Charlotte Breum-Leer; Ulrich Fredberg; Henny Jørgensen; Birgitte Brock |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-03 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: 106 ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-07 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: Denmark |
Other Details:
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Languages: eng Pagination: 422-7 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark. ml@farm.au.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Denmark Drug Interactions Humans Length of Stay Medication Errors / prevention & control* Medication Therapy Management* Patient Care Pharmacists Pharmacology, Clinical Physicians Polypharmacy Primary Health Care |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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