Document Detail


Effect of surface properties on nanoparticle-cell interactions.
MedLine Citation:
PMID:  19844908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.
Authors:
Ayush Verma; Francesco Stellacci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Small (Weinheim an der Bergstrasse, Germany)     Volume:  6     ISSN:  1613-6829     ISO Abbreviation:  Small     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-04     Completed Date:  2010-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235338     Medline TA:  Small     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  12-21     Citation Subset:  IM    
Affiliation:
Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / chemistry*
Cell Physiological Phenomena*
Cells, Cultured / chemistry*
Materials Testing
Nanostructures / chemistry*,  ultrastructure*
Nanotechnology / methods*
Particle Size
Surface Properties*
Chemical
Reg. No./Substance:
0/Biocompatible Materials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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