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Effect of Successive Single-gestation Pregnancies on the Course of Maternal Human Immunodeficiency Virus Disease and Perinatal Transmission.
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MedLine Citation:
PMID:  18475404     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: This study was undertaken to examine the effect of successive pregnancies over a 3-year period on the course of maternal human immunodeficiency virus (HIV) infection and the rate of perinatal transmission of HIV.Methods: A retrospective analysis of 32 pregnancies in 14 known HIV-infected women vs. a matched control group of HIV-infected women who had been pregnant only once was done.Results: The multiple-pregnancy group was similar to the single-pregnancy group for age, race, duration of known HIV infection, initial CD(4) count, and date of first pregnancy. The delivery data were similar as well. The CD(4) counts in the multiple-pregnancy group fell from 595 to 460, while counts in the single-pregnancy group fell comparably from 669 to 638, both over 37 months (P = 0.1476). Five of 5 second-born infants of known serostatus vs. 8 of 21 first-born infants were HIV-infected (P < 0.05).Conclusions: Successive pregnancies do not alter the course of HIV infection in asymptomatic women followed up to 3 years. The infants of second pregnancies of known HIV-infected women may be at higher risk for perinatal transmission.
Authors:
W R Robinson; D Wiley; R Van Dyke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  2     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  1995  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  251-4     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology Tulane University School of Medicine Box SL 11 1430 Tulane Avenue New Orleans LA 70112 USA.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1995 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 11 Month: 8 Year: 1994
Accepted Day: 27 Month: 1 Year: 1995
Print publication date: Year: 1995
Volume: 2 Issue: 6
First Page: 251 Last Page: 254
ID: 2364399
PubMed Id: 18475404
Publisher Item Identifier: S1064744995000135
DOI: 10.1155/S1064744995000135

Effect of Successive Single-gestation Pregnancies on the Course of Maternal Human Immunodeficiency Virus Disease and Perinatal Transmission
William R. Robinson1
Dan Wiley3
Russ Van Dyke2
1Department of Obstetrics and GynecologyTulane University School of MedicineBox SL 111430 Tulane AvenueNew OrleansLA70112USA
2Department of PediatricsTulane University School of MedicineNew OrleansLAUSA
3Department of Medicine St. Mary's HospitalSan FranciscoCAUSA


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