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Effect of Subthalamic Nucleus Deep Brain Stimulation on the Autonomic Nervous System in Parkinson's Disease Patients Assessed by Spectral Analyses of R-R Interval Variability and Blood Pressure Variability.
MedLine Citation:
PMID:  22699844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Autonomic nervous system impairment is an untoward symptom that is typically observed in advanced Parkinson's disease (PD) patients. However, details of the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on the autonomic nervous system remain unclear. Methods: Twenty-eight patients with advanced PD (12 males and 16 females) who underwent bilateral STN-DBS and 13 age-matched healthy controls were included in this study. We analyzed the dynamic cardiovascular autonomic function regulating the R-R interval and blood pressure by spectral and transfer function analyses of cardiovascular variability before and after STN-DBS. Results: Vagally mediated arterial-cardiac baroreflex function improved after STN-DBS compared to that before STN-DBS (p < 0.05). However, there were no statistically significant differences in the results of the comparison of vagally mediated arterial-cardiac baroreflex function between on-stimulation and off-stimulation. Conclusions: The vagal component in cardiac autonomic dysfunction associated with PD is expected to improve after STN-DBS. We considered that the patients improved their lifestyle; in particular, increasing the amount of exercise by STN-DBS and the best pharmachological treatment may have positive effects on parasympathetic activities.
Authors:
Koichiro Sumi; Yoichi Katayama; Toshiharu Otaka; Toshiki Obuchi; Toshikazu Kano; Kazutaka Kobayashi; Hideki Oshima; Chikashi Fukaya; Takamitsu Yamamoto; Yojiro Ogawa; Kenichi Iwasaki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-14
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  90     ISSN:  1423-0372     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  248-254     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Division of Neurosurgery, Nihon University School of Medicine, Tokyo, Japan.
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