| Effect of Sub-MICs of antibiotics on the hydrophobicity and production of acidic polysaccharide by Vibrio vulnificus. | |
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MedLine Citation:
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PMID: 11306787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Subinhibitory concentrations of antibiotics, which can occur in vivo, have been demonstrated to alter the production of bacterial virulence factors, including the capsule, or the interaction between microorganism and phagocyte by affecting surface hydrophobicity. METHODS: Using a microtiter assay system, the effect of subinhibitory concentrations of amikacin, gentamicin, cephalothin and doxycycline on the surface hydrophobicity and production of acidic polysaccharide by Vibrio vulnificus (8 human isolates, 8 environmental isolates) was determined. RESULTS: All four drugs, in a dose-dependent manner, caused alterations in adherence to polystyrene, a measure of surface hydrophobicity, and the production of acidic polysaccharides, as determined by Alcian blue staining. CONCLUSION: The changes in capsule production and surface hydrophobicity measured in response to sub-MICs of antibiotics appear to be independent variables. |
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Authors:
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F Farzam; B J Plotkin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemotherapy Volume: 47 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 2001 May-Jun |
Date Detail:
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Created Date: 2001-04-18 Completed Date: 2001-07-19 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: Switzerland |
Other Details:
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Languages: eng Pagination: 184-93 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel |
Affiliation:
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Department of Microbiology, University of Southwestern Louisiana, Lafayette, La., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Capsules Cell Adhesion Dose-Response Relationship, Drug Humans Polysaccharides / chemistry* Polystyrenes Vibrio / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Capsules; 0/Polysaccharides; 0/Polystyrenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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