Document Detail

Effect of Sub-MICs of antibiotics on the hydrophobicity and production of acidic polysaccharide by Vibrio vulnificus.
MedLine Citation:
PMID:  11306787     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Subinhibitory concentrations of antibiotics, which can occur in vivo, have been demonstrated to alter the production of bacterial virulence factors, including the capsule, or the interaction between microorganism and phagocyte by affecting surface hydrophobicity. METHODS: Using a microtiter assay system, the effect of subinhibitory concentrations of amikacin, gentamicin, cephalothin and doxycycline on the surface hydrophobicity and production of acidic polysaccharide by Vibrio vulnificus (8 human isolates, 8 environmental isolates) was determined. RESULTS: All four drugs, in a dose-dependent manner, caused alterations in adherence to polystyrene, a measure of surface hydrophobicity, and the production of acidic polysaccharides, as determined by Alcian blue staining. CONCLUSION: The changes in capsule production and surface hydrophobicity measured in response to sub-MICs of antibiotics appear to be independent variables.
F Farzam; B J Plotkin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemotherapy     Volume:  47     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-04-18     Completed Date:  2001-07-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  184-93     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Department of Microbiology, University of Southwestern Louisiana, Lafayette, La., USA.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Cell Adhesion
Dose-Response Relationship, Drug
Polysaccharides / chemistry*
Vibrio / physiology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Capsules; 0/Polysaccharides; 0/Polystyrenes

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