| The effect of statin therapy on ventricular tachyarrhythmias: a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 20720485 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The objective of this study was to assess whether statin therapy is associated with a reduction in ventricular tachyarrhythmias. Statins have been shown to be beneficial beyond their cholesterol-lowering effects. These pleiotropic effects have been implicated in the protection against atrial fibrillation and the reduction in appropriate implantable cardioverter-defibrillator therapy in patients with coronary artery disease. This meta-analysis was conducted to evaluate whether statins were associated with a reduction in ventricular tachyarrhythmias in patients with coronary artery disease or nonischemic cardiomyopathy. The Medline and Cochrane databases were searched for studies in human subjects published in the English language between 1985 and February 2010. Studies were included in our analysis if they provided data regarding the association between the use of statins and the incidence of ventricular tachycardia/ventricular fibrillation (VT/VF) in patients with coronary artery disease or nonischemic cardiomyopathy. The occurrence of ventricular arrhythmias was defined as the VT/VF occurrence or appropriate implantable cardioverter-defibrillator therapy for VT/VF. Of the 166 identified articles, nine prospective studies with 150,953 patients enrolled met our inclusion criteria and were included in this analysis. Using a random effects model, statin therapy was associated with a 31% reduction in the risk of VT/VF when compared with the group not on statin therapy (pooled relative risk = 0.69, 95% confidence interval, 0.58-0.83; heterogeneity I = 57.3%). There was a low likelihood of publication bias in this analysis (Egger's test P = 0.957). Statin use in patients with coronary artery disease or nonischemic cardiomyopathy is associated with a 31% reduction in the development of ventricular tachyarrhythmias. |
| | |
Authors:
|
Nikolas Wanahita; Jennifer Chen; Sripal Bangalore; Kunal Shah; Maurice Rachko; Craig I Coleman; Paul Schweitzer |
Related Documents
:
|
9595505 - Increased monophasic action potential dispersion in endothelin-1-induced ventricular ar... 6702645 - Significance of ventricular arrhythmias in idiopathic dilated cardiomyopathy. 7845835 - Intraoperative mapping is not necessary for vt surgery. 3792355 - Incidence, clinical significance and prognosis of ventricular fibrillation in the early... 19450055 - Long-term secondary prevention programs after cardiac rehabilitation for the reduction ... 21068705 - Evaluation of oxygen delivery in a patient with berlin excortm biventricular support. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of therapeutics Volume: 19 ISSN: 1536-3686 ISO Abbreviation: Am J Ther Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 16-23 Citation Subset: IM |
Affiliation:
|
1Division of Cardiology, Beth Israel Medical Center, New York, NY; 2Division of Cardiology, Hartford Hospital, Hartford and the University of Connecticut Schools of Pharmacy and Medicine, Storrs and Farmington, CT; and 3Division of Cardiology, Brigham and Women's Hospital, Boston, MA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Use of heptaminol hydrochloride for catecholamine weaning in septic shock.
Next Document: Efficacy of hybrid therapy in the form of right atrial ablation and adjunctive therapy in refractory...