Document Detail


Effect of Solanum torvum on blood pressure and metabolic alterations in fructose hypertensive rats.
MedLine Citation:
PMID:  19683046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum torvum (Solanaceae) is a plant used in Cameroon ethnomedicine for the treatment of hypertension. AIM OF THE STUDY: The present study was aimed to determine the effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, insulin and uric acid in fructose-induced hypertension. MATERIALS AND METHODS: The effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on fructose (10%) induced rise in blood pressure was tested by invasive and non-invasive measurements and the biochemical parameters were studied by using standard kits. RESULTS: Ethanolic extract of Solanum torvum reduced systolic blood pressure, vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose. The cumulative concentration response curve (CCRC) of Angiotensin II (Ang II) using isolated strip of ascending colon was shifted towards right in rats treated with ethanolic extract of Solanum torvum. CONCLUSIONS: In conclusion, ethanolic extract of Solanum torvum could prevent the development of high blood pressure induced by a diet rich in fructose probably by reversing the metabolic alterations induced by fructose.
Authors:
Mahalaxmi Mohan; Bhagat Singh Jaiswal; Sanjay Kasture
Related Documents :
10919856 - Renal interstitial hydrostatic pressure and pressure natriuresis in pregnant rats.
10523366 - Cardiopulmonary reflex impairment in experimental diabetes in rats.
25317776 - Non-invasive positive pressure ventilation following esophagectomy: safety demonstrated...
3346046 - Extent of baroreceptor resetting in response to sodium nitroprusside and verapamil.
3994136 - Effect of protective padding on forelimb intracompartmental muscle pressures in anesthe...
158966 - Echocardiographic dimensions in borderline and sustained hypertension.
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-08-13
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  126     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  86-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, MGV's Pharmacy College, Panchavati, Nasik, Maharashtra, India. mm_nasik@yahoo.co.in
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin II / antagonists & inhibitors,  pharmacology
Animals
Antihypertensive Agents / therapeutic use*
Blood Glucose / drug effects
Blood Pressure / drug effects*
Body Weight / drug effects
Cholesterol / blood
Colon, Ascending / drug effects
Drug Evaluation, Preclinical
Fructose
Fruit
Insulin / blood
Male
Medicine, African Traditional
Phytotherapy / methods*
Plant Extracts / therapeutic use*
Rats
Rats, Wistar
Solanum / chemistry*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Blood Glucose; 0/Plant Extracts; 0/Triglycerides; 11061-68-0/Insulin; 11128-99-7/Angiotensin II; 30237-26-4/Fructose; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Quality and safety of Chinese herbal medicines guided by a systems biology perspective.
Next Document:  Evidence that the major metabolites accumulating in hyperornithinemia-hyperammonemia-homocitrullinur...