Document Detail

Effect of Solanum torvum on blood pressure and metabolic alterations in fructose hypertensive rats.
MedLine Citation:
PMID:  19683046     Owner:  NLM     Status:  MEDLINE    
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum torvum (Solanaceae) is a plant used in Cameroon ethnomedicine for the treatment of hypertension. AIM OF THE STUDY: The present study was aimed to determine the effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, insulin and uric acid in fructose-induced hypertension. MATERIALS AND METHODS: The effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on fructose (10%) induced rise in blood pressure was tested by invasive and non-invasive measurements and the biochemical parameters were studied by using standard kits. RESULTS: Ethanolic extract of Solanum torvum reduced systolic blood pressure, vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose. The cumulative concentration response curve (CCRC) of Angiotensin II (Ang II) using isolated strip of ascending colon was shifted towards right in rats treated with ethanolic extract of Solanum torvum. CONCLUSIONS: In conclusion, ethanolic extract of Solanum torvum could prevent the development of high blood pressure induced by a diet rich in fructose probably by reversing the metabolic alterations induced by fructose.
Mahalaxmi Mohan; Bhagat Singh Jaiswal; Sanjay Kasture
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-08-13
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  126     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  86-9     Citation Subset:  IM    
Department of Pharmacology, MGV's Pharmacy College, Panchavati, Nasik, Maharashtra, India.
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MeSH Terms
Angiotensin II / antagonists & inhibitors,  pharmacology
Antihypertensive Agents / therapeutic use*
Blood Glucose / drug effects
Blood Pressure / drug effects*
Body Weight / drug effects
Cholesterol / blood
Colon, Ascending / drug effects
Drug Evaluation, Preclinical
Insulin / blood
Medicine, African Traditional
Phytotherapy / methods*
Plant Extracts / therapeutic use*
Rats, Wistar
Solanum / chemistry*
Triglycerides / blood
Reg. No./Substance:
0/Antihypertensive Agents; 0/Blood Glucose; 0/Plant Extracts; 0/Triglycerides; 11061-68-0/Insulin; 11128-99-7/Angiotensin II; 30237-26-4/Fructose; 57-88-5/Cholesterol

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