Document Detail

Effect of sodium fluoride, ampicillin, and chlorhexidine on Streptococcus mutans biofilm detachment.
MedLine Citation:
PMID:  22664966     Owner:  NLM     Status:  MEDLINE    
We examined the effect of three clinically used antimicrobials on Streptococcus mutans UA159 biofilm detachment under flow conditions. Sodium fluoride (NaF) and chlorhexidine at MIC levels promoted biofilm detachment and inhibited detachment when concentrations were higher than the MIC and reduced detached-cell viability only at high concentrations. Ampicillin at all concentrations tested inhibited detachment and reduced the percentage of viable biofilm-detached cells. All the three antimicrobial treatments reduced biofilm live/dead cell ratios.
Jia Liu; Jun-Qi Ling; Kai Zhang; Li-Jun Huo; Yang Ning
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-04
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-24     Completed Date:  2013-02-12     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4532-5     Citation Subset:  IM    
Institute of Stomatological Research, Guanghua School of Stomotology, Sun Yat-sen University, Guangzhou, China.
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MeSH Terms
Ampicillin / pharmacology*
Anti-Bacterial Agents / pharmacology
Anti-Infective Agents, Local / pharmacology
Biofilms / drug effects*
Cariostatic Agents / pharmacology
Chlorhexidine / pharmacology*
Microbial Sensitivity Tests
Sodium Fluoride / pharmacology*
Streptococcus mutans / drug effects*,  physiology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 0/Cariostatic Agents; 55-56-1/Chlorhexidine; 69-53-4/Ampicillin; 7681-49-4/Sodium Fluoride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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