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The Effect of Sodium Acetate Ingestion on the Metabolic Response to Prolonged Moderate-Intensity Exercise in Humans.
MedLine Citation:
PMID:  23296954     Owner:  NLM     Status:  Publisher    
At rest administration of the short chain fatty acid acetate suppresses fat oxidation without affecting carbohydrate utilisation. The combined effect of increased acetate availability and exercise on substrate utilisation is however, unclear. With local ethics approval we studied the effect of ingesting either sodium acetate (NaAc) or sodium bicarbonate (NaHCO3) at a dose of 4 mmol·kg-1 body mass 90 min prior to completing 120 min of exercise at 50% VO2peak. Six healthy young men completed the trials after an overnight fast and ingested the sodium salts in randomized order. As expected NaAc ingestion decreased resting fat oxidation (mean ± SD; 0.09 ± 0.02 vs. 0.07 ± 0.02 g·min-1 pre- and post-ingestion respectively, P < .05) with no effect upon carbohydrate utilisation. In contrast, NaHCO3 ingestion had no effect on substrate utilisation at rest. In response to exercise fat and CHO oxidation increased in both trials but fat oxidation was lower (0.16 ± 0.10 vs. 0.29 ± 0.11 g·min-1, P < .05) and carbohydrate oxidation higher (1.67 ± 0.35 vs. 1.44 ± 0.22 g·min-1, P < .05) in the NaAc trial compared with the NaHCO3 trial during the first 15 min of exercise. Over the final 75 min of exercise an increase in fat oxidation and decrease in carbohydrate oxidation was observed only in the NaAc trial. These results demonstrate that increasing plasma acetate concentration suppresses fat oxidation both at rest and at the onset of moderate-intensity exercise.
Gordon I Smith; Asker E Jeukendrup; Derek Ball
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  -     ISSN:  1543-2742     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland and the School of Medicine, Washington University, St. Louis, MO.
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